Maternal macronutrient and energy intakes in pregnancy and offspring intake at 10 y: exploring parental comparisons and prenatal effects.
Maternal macronutrient and energy intakes in pregnancy and offspring intake at 10 y: exploring parental comparisons and prenatal effects.
复制标题
DOI：
10.3945/ajcn.2009.28623
复制
发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Lawlor DA
中科院分区：
文献类型：
--
作者：
Brion MJ;Ness AR;Rogers I;Emmett P;Cribb V;Davey Smith G;Lawlor DA
背景资料：母亲在怀孕期间的高饮食摄入量可能会导致胎儿生长增加，并编程神经内分泌途径，导致后代在以后的生活中食欲更大，能量摄入量更大，肥胖症。很少有前瞻性的饮食研究探讨了这种关系。目的：目的是评估母亲在怀孕期间的饮食摄入量和母亲和父亲的饮食摄入量与儿童的饮食摄入量和肥胖的关系。设计图：前瞻性地评估了母亲在怀孕期间、母亲及其伴侣在出生后47个月以及儿童在10年时的能量、蛋白质、总脂肪和碳水化合物的膳食摄入量（n = 5717对母亲-儿童对产前、5593对母亲-儿童对出生后和3009对父亲-儿童对）。在9岁和11岁时评估儿童身体成分（n = 5725）。结果如下：母亲膳食摄入的蛋白质，脂肪（当调整能量摄入量），碳水化合物在怀孕期间与儿童膳食摄入相同的营养素呈正相关，这些协会大于父亲的饮食摄入量，这是没有强烈的关联与后代的饮食。母体产前-子代蛋白质和脂肪摄入量的相关性强于母体产后-子代蛋白质和脂肪摄入量的相关性。当调整潜在能量低报时，儿童能量和大量营养素摄入量增加仅与儿童肥胖增加相关。母亲怀孕期间的饮食与后代肥胖或瘦体重无关。结论：与父亲的摄入量协会和母亲的产后摄入量协会相比，更强的产前母亲与儿童饮食摄入量，特别是蛋白质和脂肪的协会提供了一些证据，在子宫内编程的后代食欲母亲在怀孕期间的摄入量。
Background: High maternal dietary intakes in pregnancy may lead to increased fetal growth and program neuroendocrine pathways that result in greater appetite, energy intake, and adiposity in offspring later in life. Few prospective dietary studies have explored this relation. Objective: The objective was to assess associations of maternal dietary intake in pregnancy and maternal and paternal dietary intake postnatally with child dietary intake and adiposity. Design: Dietary intakes of energy, protein, total fat, and carbohydrate were assessed prospectively in mothers during pregnancy, in mothers and their partners at 47 mo postnatally, and in children at 10 y (n = 5717 mother-child pairs prenatally, 5593 mother-child pairs postnatally, and 3009 father-child pairs). Child body composition was assessed at 9 and 11 y (n = 5725). Results: Maternal dietary intakes of protein, fat (when adjusted for energy intake), and carbohydrate in pregnancy were positively associated with child dietary intakes of the same nutrients, and these associations were greater than those observed for paternal dietary intake, which was not strongly associated with offspring diet. Associations of maternal prenatal-offspring intakes were stronger than those of maternal postnatal-offspring intakes for protein and fat. Greater child energy and macronutrient intakes were only associated with greater adiposity in children when adjusted for potential energy underreporting. Maternal diet during pregnancy was not associated with offspring adiposity or lean mass. Conclusion: The stronger prenatal maternal associations with child dietary intake, particularly protein and fat, compared with both paternal intake associations and maternal postnatal intake associations provide some evidence for in utero programming of offspring appetite by maternal intake during pregnancy.
登录
查看更多内容
DOI：
10.3945/jn.109.109579
发表时间：
2009-10
期刊：
The Journal of nutrition
影响因子：
--
作者：
Crozier SR;Robinson SM;Godfrey KM;Cooper C;Inskip HM
通讯作者：
Inskip HM
影响因子：
7.2
作者：
Major, CA;Henry, MJ;Morgan, MA
通讯作者：
Morgan, MA
影响因子：
16.2
作者：
COMBS, CA;GUNDERSON, E;MAIN, EK
通讯作者：
MAIN, EK
DOI：
10.1016/0002-9378(91)90637-7
发表时间：
1991-01-01
影响因子：
9.8
作者：
JOVANOVICPETERSON, L;PETERSON, CM;AARONS, JH
通讯作者：
AARONS, JH
影响因子：
8.3
作者：
Brion, Marie-Jo A.;Leary, Sam D.;Ness, Andy R.
通讯作者：
Ness, Andy R.