Immunokinetics of autoreactive CD4 T cells in blood: a reporter for the "hit-and-run" autoimmune attack on pancreas and diabetes progression.
Immunokinetics of autoreactive CD4 T cells in blood: a reporter for the "hit-and-run" autoimmune attack on pancreas and diabetes progression.
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血液中自身反应性 CD4 T 细胞的免疫动力学：胰腺“肇事逃逸”自身免疫攻击和糖尿病进展的报告者。
DOI：
10.1016/j.jaut.2004.06.006
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Casares,Sofia
中科院分区：
文献类型：
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作者：
George,SunilK;Preda,Ioana;Avagyan,Serine;McEvoy,RobertC;Rapaport,Robert;Brumeanu,Teodor-Doru;Casares,Sofia
人们对血液中自身反应性CD4 T细胞的命运知之甚少。利用小鼠自发性自身免疫性糖尿病模型，我们证明了胰腺自身免疫过程的状态可以通过血液中自身反应性CD4 T细胞的频率和表型来描绘。在糖尿病前期早期，这些细胞在血液中的频率减少，这是它们在胰腺中聚集的结果。随后，胰腺中CD4+CD25+和CD4+CD69+T细胞之间的不平衡反映在血液中自身反应性T细胞的表型中。在疾病发作之前，血液中CD4+CD69+T细胞的激活波表明，对胰腺的自身免疫攻击是一个不连续的“打了就跑”，而不是一个连续的过程。跟踪血液中的自身反应性CD4 T细胞可能有助于识别糖尿病前期患者并在治疗干预期间监测疾病进展。
Little is known about the fate of autoreactive CD4 T cells in blood. Using a mouse model for spontaneous autoimmune diabetes we demonstrated that the status of the autoimmune process in pancreas could be pictured through the frequency and phenotype of autoreactive CD4 T cells in the blood. Early during the prediabetic stage, the frequency of these cells in blood decreased as a consequence of their recruitment in the pancreas. This was followed by an imbalance between CD4+CD25+and CD4+CD69+T cells in the pancreas that was mirrored in the phenotype of autoreactive T cells in the blood. Waves of activated CD4+CD69+T cells in blood preceded the disease onset suggesting that the autoimmune attack on pancreas is a discontinuous “hit-and-run” rather than a continuous process. Tracking autoreactive CD4 T cells in blood may help in identifying prediabetic humans and monitoring the disease progression during therapeutic interventions.