Macrophage polarization in response to epigenetic modifiers during infection and inflammation.
Macrophage polarization in response to epigenetic modifiers during infection and inflammation.
复制标题
DOI：
10.1016/j.drudis.2016.08.006
复制
发表时间：
2017-01
影响因子：
7.4
通讯作者：
Rajasingh J
中科院分区：
文献类型：
--
作者：
Patel U;Rajasingh S;Samanta S;Cao T;Dawn B;Rajasingh J
巨噬细胞是存在于所有组织中的异质性吞噬细胞群。最近，几种针对表观遗传机制的药物已经成为通过调节巨噬细胞来治疗感染和炎症的有吸引力的分子。用表观遗传修饰剂处理脂多糖(LPS)攻击的巨噬细胞会导致表型转换。这可以提供刺激/破坏性(M1)或抑制/保护(M2)治疗策略，这在巨噬细胞所处的细胞因子环境中是至关重要的。在这篇综述中，我们概述了巨噬细胞在包括感染在内的各种疾病中的功能多样性，以及表观遗传修饰物的开发和临床应用的现状。
Macrophages are a heterogeneous population of phagocytic cells present in all tissues. Recently, several drugs that target the epigenetic machinery have emerged as attractive molecules for treating infection and inflammation by modulating macrophages. Treatment of lipopolysaccharide (LPS)-challenged macrophages with epigenetic modifiers leads to phenotype switching. This could provide stimulatory/destructive (M1) or suppressive/protective (M2) therapeutic strategies, which are crucial in the cytokine milieu in which the macrophages reside. In this review, we provide an overview of macrophage functional diversity during various diseases, including infection, as well as the current status in the development and clinical utility of epigenetic modifiers.