Cellular regulation.
Cellular regulation.
复制标题
细胞调节。
DOI：
10.1126/science.216.4553.1403
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发表时间：
1982
期刊：
影响因子：
56.9
通讯作者：
J. Putney
中科院分区：
文献类型：
--
作者：
J. Putney
关于Rasmu ssen的专著是与细胞内稳态的关系，以及两个最明确的生物学”第二信使”，钙和环AMP之间的关系。拉斯穆森是第一个在十多年前发表的一篇重要评论中呼吁关注这些第二信使之间关系的人之一（Science 170，404 [1970]）。这本专著用来说明70年代的实验如何大大增加了我们对这一主题的知识。从历史上看，我们对钙的生物重要性的认识可以追溯到近一百年前林格最初的观察，即肌肉收缩需要钙。然而，只有在过去的20年里，钙作为其他细胞反应（如分泌和代谢）的介质的一般作用才得到充分认识。20世纪50年代，Sutherland发现了环AMP及其作为肝脏激素作用介质的作用，随后引起了大量的再灌注，
The theme of Rasmu. ssen's monograph is the relationship to cell homeostasis and to one another of the two most clearly established biological" second messengers," calcium and cyclic AMP. Rasmussen was one of the first to call attention to the relationships between these second messengers in an important review appearing over ten years ago (Science 170, 404 [1970]). This mono-graph serves to illustrate how experi-mentation during the'70's has added substantially to our knowledge of this topic.Historically, our appreciation of the biological importance of calcium dates back almost a hundred years to Ringer's original observation that muscle contrac-tion requires calcium. Only in the last 20 years, however, has the general role of calcium as a mediator of other cellular responses (such as secretion and metabolism) come to be fully realized. The discovery inthe 1950's by Sutherland of cyclic AMP and its role as a mediator of hormone action in the liver subsequently spawned a considerable quantity of re-