A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
复制标题
甲硝唑治疗慢性牙周病 3 年后的随访研究。
DOI：
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发表时间：
1986
影响因子：
6.7
通讯作者：
R. Duckworth
中科院分区：
文献类型：
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作者：
S. Joyston;F. Smales;R. Duckworth
在先前的一项研究中，在45名患有慢性牙周病的受试者中完成了甲硝唑和安慰剂片剂效果的双盲比较，这些受试者的严重程度从中度（PI = 2.0-3.9）到高度（PI = 4.0-6.0）。结果显示，使用甲硝唑后，牙周袋的平均探诊深度明显减少，但这种减少仅在严重牙周病患者中明显（PI = 4.0-6.0）。3年后，28名受试者参加了研究。与首次访视时相比，所有组的所有参数仍显示出统计学显著性改善。然而，与试验结束时相比，牙龈出血和牙石评分在统计学上显著增加。还观察到菌斑水平增加，但无统计学显著性。当中度和重度牙周病的受试者被分组在一起时，试验组和对照组之间的任何参数都没有显著差异。此外，在试验结束时，严重组使用甲硝唑后，囊袋平均探诊深度显著降低，但3年后消失。然而，在患有轻度疾病的受试者中，3年后观察到口袋探测深度在统计学上显着减少，而最初并不明显。
In a previous study, a double-blind between subject comparison of the effects of metronidazole and placebo tablets was completed over 22 weeks in 45 subjects with chronic periodontal disease ranging in severity from moderate (PI = 2.0-3.9) to high (PI = 4.0-6.0). The results showed a significantly greater reduction in the mean probing depth of pockets with the use of metronidazole, but this reduction was apparent only in subjects with severe periodontal disease (PI = 4.0-6.0). 3 years later, 28 subjects attended. All groups still showed statistically significant improvements in all parameters when compared with those at the first visit. However, when compared with those at the end of the trial, there were statistically significant increases in gingival bleeding and calculus scores. An increase in plaque levels was also observed but this was not statistically significant. When subjects with moderate and severe periodontal disease were grouped together, there were no significant differences in any of the parameters between test and control groups. Moreover, the significantly greater reductions in mean probing depth of pockets, achieved with the use of metronidazole in the severe group at the end of the trial, had disappeared after 3 years. However, in subjects with mild disease, statistically significant reductions in pocket probing depth, not originally apparent, were observed 3 years later.