Structural changes of the retina in retinal vein occlusion--imaging and quantification with optical coherence tomography.
Structural changes of the retina in retinal vein occlusion--imaging and quantification with optical coherence tomography.
复制标题
视网膜静脉阻塞时视网膜的结构变化——光学相干断层扫描成像和定量。
DOI：
10.3928/1542-8877-20010701-03
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
G. Richard
中科院分区：
文献类型：
--
作者：
Ralf;U. Schaudig;F. Scholz;A. Walter;G. Richard
背景与目的
评价光学相干断层扫描（OCT）成像和定量静脉闭塞性疾病后视网膜结构变化的潜力。
患者和方法
我们研究了20例视网膜静脉阻塞患者，其中5例为视网膜分支静脉阻塞（BRVO），15例为视网膜中央静脉阻塞（CRVO）。CRVO患者在首次出现症状后72小时内进行研究。在完成包括荧光素血管造影在内的完整眼科检查后，对患者进行OCT检查。通过固定中心进行一组标准线性扫描，并对特别感兴趣的区域进行单独扫描。对扫描进行定性评价，并在线性扫描的5个位置对单次A扫描进行定量测量。在注视中心、中心凹边缘和扫描边缘进行测量。我们测量了视网膜总厚度、囊样间隙厚度和高反射外带厚度。
结果
OCT产生视网膜增厚、视网膜内和视网膜下出血、视网膜内和视网膜下积液以及视网膜内囊样间隙形成的详细图像。定量评估显示，视网膜中央静脉阻塞患者的平均视网膜中央厚度为274 +/- 181微米（72-760微米）。视力与中央或中心凹外视网膜厚度无关。
结论
光学相干断层扫描是一种有用的成像技术，用于研究静脉阻塞性疾病后视网膜结构的变化。即使是微小的变化，如局部视网膜下积液或开始视网膜前膜形成，也可以详细观察到。与其他疾病如糖尿病性黄斑病变相比，黄斑厚度的定量评估与视力无关。尽管如此，由于详细的成像，光学相干断层扫描可能成为一个有用的工具，在后续行动和治疗的个别患者。
BACKGROUND AND OBJECTIVE
To evaluate the potential of optical coherence tomography (OCT) for imaging and quantifying structural changes in the retinal architecture following venous occlusive disease.
PATIENTS AND METHODS
We studied 20 patients with retinal venous occlusive disease: 5 patients suffered from branch retinal vein occlusion (BRVO), and 15 from central retinal vein occlusion (CRVO). Patients with CRVO were studied within 72 hours after the first onset of symptoms. Patients were examined by OCT after a complete ophthalmologic examination including fluorescein angiography. A standard set of linear scans through the center of fixation and individual scans over areas of special interest were performed. Scans were qualitatively evaluated and quantitative measurements were performed on single A-scans at 5 locations of linear scans. Measurements were taken in the center of fixation, at the foveal rim, and at the edge of the scan. We measured total retinal thickness, thickness of cystoid spaces, and thickness of the highly reflective outer band.
RESULTS
OCT produced detailed images of retinal thickening, intra- and subretinal hemorrhage, intra- and subretinal fluid accumulation, and formation of intraretinal cystoid spaces. Quantitative evaluation revealed a mean central retinal thickness of 274 +/- 181 microm (72-760 microm) in patients with central retinal vein occlusion. Visual acuity did not correlate with central or extrafoveal retinal thickness.
CONCLUSION
Optical coherence tomography is a useful imaging technique for studying changes of retinal architecture following venous occlusive disease. Even minor changes like localized subretinal fluid accumulation or beginning epiretinal membrane formation can be visualized in detail. In contrast to other diseases like diabetic maculopathy, quantitative assessment of macular thickness does not correlate to visual acuity. Nevertheless, because of detailed imaging, OCT might become a useful tool in the follow-up and treatment of individual patients.