Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities.
Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities.
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DOI：
10.1016/j.nicl.2015.09.009
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Cohen AD
中科院分区：
文献类型：
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作者：
Goodheart AE;Tamburo E;Minhas D;Aizenstein HJ;McDade E;Snitz BE;Price JC;Mathis CA;Lopez OL;Klunk WE;Cohen AD
淀粉样显像剂匹兹堡化合物-B与大脑中的β-淀粉样蛋白(A-β)具有高亲和力，众所周知，PIB也显示出非特异性的白质滞留。然而，对白质高信号(WMH)区的PIB滞留知之甚少，这是老年人常见的异常现象。此外，还假设WMH与认知功能障碍和Aβ沉积有关。本研究的目的是探索在一组认知正常的老年个体中，外表正常的WM(NAWM)和WMH中的PIB保留。在一组认知正常的老年人(n=；86.50±12.6岁)中，进行了两项分析：(1)ROI被放置在脑室周围区域，在那里所有受试者都可以看到WMH帽，而无论WMH负荷或大小。(2)将NAWM图和WMH图与PIB-PET图像配准，计算NAWM图和WMH图的平均SUVR值。与低WMH受试者相比，高WMH受试者的ROI中PIB滞留显著减少。此外，在高WMH的受试者中，与NAWM相比，WMH的受试者特定地图组的PIB保留率显著低于NAWM，这在低WMH的受试者中没有观察到，可能是因为这一组WMH图的尺寸较小。这些数据表明，WMH区域的WM与PIB的结合效率低于正常WM。对这一现象的进一步探索可能会导致对淀粉样蛋白示踪剂在白质中非特异性保留的分子基础的深入了解。与低WMH受试者相比，高WMH受试者的“典型WMH”感兴趣区的PIB滞留显著减少。在高WMH的受试者中，与NAWM相比，WMH的受试者特定地图中的PIB保留率显著低于NAWM。这些数据表明，WMH区域的WM与PIB的结合效率低于正常WM。
The amyloid imaging agent, Pittsburgh Compound-B, binds with high affinity to β-amyloid (Aβ) in the brain, and it is well established that PiB also shows non-specific retention in white matter (WM). However, little is known about retention of PiB in areas of white matter hyperintensities (WMH), abnormalities commonly seen in older adults. Further, it is hypothesized that WMH are related to both cognitive dysfunction and Aβ deposition. The goal of the present study was to explore PiB retention in both normal-appearing WM (NAWM) and WMH in a group of elderly, cognitively normal individuals. In a group of cognitively normal elderly (n = 64; 86.5 ± 2.6 years) two analyses were applied: (1) ROIs were placed over periventricular areas in which WMH caps are commonly seen on all subjects, regardless of WMH burden or size. (2) Subject-specific maps of NAWM and WMH were co-registered with the PiB-PET images and mean SUVR values were calculated in these NAWM and WMH maps. PiB retention was significantly reduced in the ROIs of subjects with high WMH compared to subjects with low WMH. Additionally, in subjects with high WMH, there was significantly lower PiB retention in subject-specific maps of WMH compared to NAWM, which was not observed in subjects with low WMH, likely because of the small size of WMH maps in this group. These data suggest that WM in areas of WMH binds PiB less effectively than does normal WM. Further exploration of this phenomenon may lead to insights about the molecular basis of the non-specific retention of amyloid tracers in white matter. PiB retention was significantly reduced in the “typical-WMH” ROIs of subjects with high WMH compared to subjects with low WMH. In subjects with high WMH, there was significantly lower PiB retention in subject-specific maps of WMH compared to NAWM. These data suggest that WM in areas of WMH binds PiB less effectively than does normal WM.