The Dietary Inflammatory Index Is Positively Associated with Colorectal Cancer Risk in a Chinese Case-Control Study
The Dietary Inflammatory Index Is Positively Associated with Colorectal Cancer Risk in a Chinese Case-Control Study
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DOI：
10.3390/nu12010232
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发表时间：
2020-01-01
期刊：
影响因子：
5.9
通讯作者：
Zhang, Cai-Xia
中科院分区：
文献类型：
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作者：
Abulimiti, Alinuer;Zhang, Xin;Zhang, Cai-Xia
饮食可能会调节慢性炎症。这项研究的目的是调查饮食炎症指数(DII(R))是否与中国人患结直肠癌的风险有关。中国于2010年7月至2019年4月在广州进行病例对照研究。总共招募了2502名符合条件的患者和2538名年龄(间隔5年)和性别匹配的对照组。来自有效食物频率问卷的饮食数据被用来计算能量调整DII(E-DII)分数。使用非条件Logistic回归模型估计结直肠癌风险的优势比(OR)和95%可信区间(CI)。在这项研究中，E-DII评分的范围从-5.96(最抗炎评分)到+6.01(最促炎评分)。E-DII与结直肠癌风险呈正相关，与调整潜在混杂因素后的最低四分位数相比，E-DII最高四分位数的OR=1.40(95%可信区间1.16，1.68；P趋势和0.01)。当根据癌症部位、性别、体重指数和吸烟状况进行分层时，在女性或体重过轻的人中没有观察到显著的相关性。这项研究的结果证实，在中国人群中，E-DII评分越高，患结直肠癌的风险越高。
Diet may modulate chronic inflammation. The aim of this study is to investigate whether the dietary inflammatory index (DII (R)) was associated with the risk of colorectal cancer in a Chinese population. A case-control study was conducted from July 2010 to April 2019, in Guangzhou, China. A total of 2502 eligible cases were recruited along with 2538 age- (5-year interval) and sex-matched controls. Dietary data derived from a validated food frequency questionnaire were used to calculate the energy-adjusted DII (E-DII) scores. Odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal cancer risk were estimated using unconditional logistic regression models. In this study, E-DII scores ranged from -5.96 (the most anti-inflammatory score) to +6.01 (the most pro-inflammatory score). A positive association was found between the E-DII and colorectal cancer risk, with the OR = 1.40 (95% CI 1.16, 1.68; P-trend < 0.01) for the highest E-DII quartile compared with the lowest quartile after adjusting for potential confounders. When stratified based on cancer subsite, sex, body mass index, and smoking status, significant associations were not observed in women or underweight individuals. Results from this study confirmed that a higher E-DII score was associated with an increased risk of colorectal cancer in a Chinese population.