Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function.
Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function.
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DOI：
10.3389/fncom.2017.00048
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发表时间：
2017
影响因子：
3.2
通讯作者：
Markram H
中科院分区：
文献类型：
--
作者：
Reimann MW;Nolte M;Scolamiero M;Turner K;Perin R;Chindemi G;Dłotko P;Levi R;Hess K;Markram H
神经网络结构和其涌现功能之间缺乏正式的联系，阻碍了我们对大脑如何处理信息的理解。现在，我们通过考虑突触传递的方向，构建反映信息流方向的网络图，并使用代数拓扑分析这些有向图，已经更接近于描述这种联系。将这种方法应用于新皮层的局部神经元网络，揭示了一个非常复杂且以前从未见过的突触连接拓扑结构。突触网络包含大量的神经元团，这些神经元团被束缚在空腔中，这些空腔引导相关活动的出现。在对刺激的反应中，相关的活动将突触连接的神经元结合成功能团和腔，这些功能团和腔以刻板的顺序向峰值复杂性进化。我们认为，大脑通过形成越来越复杂的功能团和腔来处理刺激。
The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission into account, constructing graphs of a network that reflect the direction of information flow, and analyzing these directed graphs using algebraic topology. Applying this approach to a local network of neurons in the neocortex revealed a remarkably intricate and previously unseen topology of synaptic connectivity. The synaptic network contains an abundance of cliques of neurons bound into cavities that guide the emergence of correlated activity. In response to stimuli, correlated activity binds synaptically connected neurons into functional cliques and cavities that evolve in a stereotypical sequence toward peak complexity. We propose that the brain processes stimuli by forming increasingly complex functional cliques and cavities.