Intracochlear inflammatory response to cochlear implant electrodes in humans.
Intracochlear inflammatory response to cochlear implant electrodes in humans.
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DOI：
10.1097/mao.0000000000000540
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发表时间：
2014-10
期刊：
影响因子：
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通讯作者：
Nadol JB Jr
中科院分区：
文献类型：
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作者：
Seyyedi M;Nadol JB Jr
本研究评估了多通道人工耳蜗植入电极附近组织反应的类型和程度。耳蜗植入电极已被分类为生物相容性假体。然而，在一些报告中，电极挤出、慢性炎症甚至植入物系统的软失效被归因于对电极的组织反应。本研究纳入了来自马萨诸塞州眼耳医院颞骨采集的所有火棉胶包埋颞骨和多通道人工耳蜗植入体。共28个颞骨从21名受试者进行了鉴定和组织学处理。细胞反应的严重程度，包括嗜酸性粒细胞和淋巴细胞浸润、巨细胞反应、新骨形成和纤维化，在沿电极沿着的三个1 mm节段上以0 - 3的量表进行评分：1-耳蜗造口处的前1 mm，电极尖端的最后1 mm，以及这些近端和远端节段之间的中间。使用Wilcoxon检验比较这些值。27例（96.4%）颞骨出现肉芽肿反应。在7例（25%）颞骨中观察到嗜酸性粒细胞浸润，提示过敏反应。在靠近耳蜗造口的耳蜗底回处，对电极的炎症反应显著大于其远端（p< 0.05）。耳蜗植入后炎症反应很常见，并且在耳蜗造口处比其远端更强烈，表明插入创伤是一个影响因素。
This study evaluates the types and degree of tissue response adjacent to the electrode of multichannel cochlear implants. cochlear implant electrodes have been classified as biocompatible prostheses. Nevertheless, in some reports, electrode extrusion, chronic inflammation and even soft failure of the implant system have been attributed to a tissue response to the electrode. All celloidin embedded temporal bones with multichannel cochlear implants from the temporal bone collection of the Massachusetts Eye and Ear Infirmary were included in the study. A total of 28 temporal bones from 21 subjects were identified and processed for histology. The severity of cellular response including eosinophil and lymphocytic infiltration, giant cell reaction, new bone formation and fibrosis were scored on a scale from 0 to 3 at three 1mm-segments along the electrode: 1- first 1mm at the cochleostomy, last 1mm from the tip of electrode, and midway between these proximal and distal segments. The values were compared using the Wilcoxon test. A granulomatous reaction to the electrode was observed in 27 (96.4%) temporal bones. Eosinophil infiltration was observed in 7 (25%) temporal bones, suggesting an allergic reaction. The Inflammatory response to the electrode was significantly greater at the basal turn of cochlea close to the cochleostomy (p< 0.05) than distal to it. An Inflammatory response is common after cochlear implantation and it is more robust at the cochleostomy than distal to it, suggesting the role of trauma of insertion as a contributing factor.