Urge-to-cough and dyspnea conceal perception of pain in healthy adults
Urge-to-cough and dyspnea conceal perception of pain in healthy adults
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DOI：
10.1016/j.resp.2012.03.010
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发表时间：
2012-04-30
影响因子：
2.3
通讯作者：
Kohzuki, Masahiro
中科院分区：
文献类型：
--
作者：
Gui, Peijun;Ebihara, Satoru;Kohzuki, Masahiro
虽然呼吸困难已被证明可以减轻疼痛，但咳嗽之前的一种呼吸道感觉--咳嗽是否对疼痛产生类似的抑制作用尚不清楚。我们研究了急咳和呼吸困难对热伤害性刺激引起的疼痛的影响。由柠檬酸刺激引起的急咳，由外吸气阻力负荷引起的呼吸困难。在两种呼吸感觉的诱导过程中，通过热痛觉阈值(TPTh)和耐受性(TPTo)来评估痛觉。TFTh和TPTo显著增加，同时伴有咳嗽和呼吸困难的感觉增加。TPTh在呼吸困难期间的变化与在急咳期间的变化显著相关。呼吸困难期间TPTo的分数变化与急咳期间的TPTo分数显著相关。这项研究表明，两种不同的呼吸系统感觉，即咳嗽和呼吸困难，都可能隐藏着疼痛的感觉。在临床环境中进一步研究这些感觉之间的相互作用是有必要的。(C)2012爱思唯尔B.V.保留所有权利。
Although dyspnea has been shown to attenuate pain, whether urge-to-cough, a respiratory sensation preceding cough, exerts a similar inhibitory effect on pain has not been clarified. We examined the effects of both urge-to-cough and dyspnea on pain induced by thermal noxious stimuli. Urge-to-cough was induced by citric acid challenge and dyspnea was induced by external inspiratory resistive loads. During inductions of two respiratory sensations, perception of pain was assessed by thermal pain threshold (TPTh) and tolerance (TPTo). TFTh and TPTo were significantly increased accompanied by increases in perception of both urge-to-cough and dyspnea. Fractional change in TPTh during dyspnea was significantly correlated with that during urge-to-cough. Fractional change in TPTo during dyspnea was significantly correlated with that during urge-to-cough. The study suggests that both two distinct respiratory sensations, i.e., urge-to-cough and dyspnea may harbor perception of pain. Further studies investigating interactions among these sensations in clinical settings are warranted. (C) 2012 Elsevier B.V. All rights reserved.