Pattern formation by vascular mesenchymal cells
Pattern formation by vascular mesenchymal cells
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DOI：
10.1073/pnas.0308436101
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发表时间：
2004-06-22
影响因子：
11.1
通讯作者：
Demer, LL
中科院分区：
文献类型：
--
作者：
Garfinkel, A;Tintut, Y;Demer, LL
在胚胎发生过程中，未成熟的间充质细胞聚集并组织成图案组织。在以后的生活中，当血管间充质细胞组织成动脉壁内的小梁骨组织时，这一过程的病理重演发生在动脉粥样硬化病变中。在这里，我们展示了多电位成人血管间充质细胞在体外自我组织成一种模式，这种模式是基于分子形态因子在反应扩散过程中相互作用的数学模型所预测的。我们确定了条纹，斑点和迷宫模式的激活剂和抑制剂形态因子，并在体外证实了模型预测。因此，反应-扩散原理可能在成体间充质细胞的形态发生过程中起重要作用。
In embryogenesis, immature mesenchymal cells aggregate and organize into patterned tissues. Later in life, a pathological recapitulation of this process takes place in atherosclerotic lesions, when vascular mesenchymal cells organize into trabecular bone tissue within the artery wall. Here we show that multipotential adult vascular mesenchymal cells self-organize in vitro into patterns that are predicted by a mathematical model based on molecular morphogens interacting in a reaction-diffusion process. We identify activator and inhibitor morphogens for stripe, spot, and labyrinthine patterns and confirm the model predictions in vitro. Thus, reaction-diffusion principles may play a significant role in morphogenetic processes in adult mesenchymal cells.