Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion.
Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion.
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外源性生长激素治疗会改变内源性生长激素分泌受损的女性的身体成分并增加自然杀伤细胞的活性。
DOI：
10.1016/0026-0495(87)90236-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kraner,JC
中科院分区：
文献类型：
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作者：
Crist,DM;Peake,GT;Mackinnon,LT;SibbittJr,WL;Kraner,JC
为了探讨人体生长激素(GH)与体成分(BC)和自然免疫(NI)之间的潜在关系，我们测定了外源性GH对GH分泌受损妇女的脂肪体重(FW)、脱脂体重(FFW)和自然杀伤细胞(NK)细胞毒活性的影响。6名未经治疗的受试者(US)和6名接受GH刺激的受试者(TS)的血清GH峰值浓度分别为6.2±1.1(扫描电子显微镜)ng/mL和5.4±1.5 ng/mL。此外，两组患者治疗前循环IGF-I水平均较低(US 684±121 mU/m L，TS 583±83 mU/m L)，且与两组联合检测前NK细胞活性水平呈正相关(r=.59，P<0.05)。TS组给予700μg人生长激素肌注，平均14天，而US组在没有GH治疗的情况下平行研究。水密度或皮褶厚度测量显示，TS组FW减少(26.1±6.8 kg至23.8±6.3 kg，P<；0.05)，FFW增加(44.9±3.3 kg至46.2±3.8 kg，P<；0.05)。在美国，FW和FFW都没有显著变化(P>；0.05)。用标准的~(51)Cr释放法检测NK细胞的特异性溶解(SL)活性，TS的SL活性从24.4±7.0%增加到44.1±8.9%(P<；0.05)，而US的水平没有明显变化(P>；0.05)。我们得出结论，每日外源性GH治疗有利于影响BC，并增加激素分泌受损的妇女的NK细胞活性。
In order to assess the potential relationship between human growth hormone (GH) and body composition (BC) and natural immunity (NI), we measured the effects of exogenous GH on fat weight (FW), fat-free weight (FFW), and the cytotoxic activity of natural killer (NK) cells in women with impaired GH secretion. Mean peak serum concentrations of GH in response tol-dopa/arginine stimulation were 6.2 ± 1.1 (SEM) ng/mL in 6 untreated subjects (US) and 5.4 ± 1.5 ng/mL in 6 GH-treated subjects (TS). Moreover, the pretreatment circulating levels of IGF-I were low in both groups (US 684 ± 121 mU/mL and TS 583 ± 83 mU/mL), and they correlated with pretest levels of NK cell activity (r= .59,P< .05) when both groups were combined. The TS were given 700 μg of human GH IM for an average of 14 days while the US were studied in parallel without GH treatment. As measured by hydrodensitometry or skinfold anthropometry, FW decreased (26.1 ± 6.8 kg to 23.8 ± 6.3 kg,P< .05) and FFW increased (44.9 ± 3.3 kg to 46.2 ± 3.8 kg,P< .05) in the TS. In the US, there were no significant (P> .05) changes in either FW or FFW. Using a standard51Cr release assay to measure the specific lytic (SL) activity of NK cells, mean SL activity increased from 24.4 ± 7.0% to 44.1 ± 8.9% (P< .05) in the TS, whereas levels in the US were not altered significantly (P> .05). We conclude that daily exogenous GH treatment favorably influences BC and increases NK cell activity in women with an impaired secretion of the hormone.