Circadian rhythms and renal pathophysiology.
Circadian rhythms and renal pathophysiology.
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DOI：
10.1172/jci148277
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发表时间：
2022-02-01
期刊：
影响因子：
--
通讯作者：
Gumz ML
中科院分区：
文献类型：
--
作者：
Mohandas R;Douma LG;Scindia Y;Gumz ML
现代生活的现实是，我们的内部昼夜节律往往与外部环境的光/暗周期不一致。这被称为昼夜节律紊乱，大量流行病学证据表明，它与心血管疾病风险增加有关。心血管疾病仍然是美国的头号死因，尤其是肾脏疾病是导致心血管死亡的巨大公共卫生负担。肾脏疾病迫切需要新的治疗方法;基于昼夜节律的治疗可能具有潜在的益处。本综述的目的是总结现有的数据，证明昼夜节律破坏和人类肾损害之间的联系。具体来说，我们将重点关注慢性肾脏疾病，狼疮性肾炎，高血压和衰老。重要的是，昼夜节律功能障碍和病理生理学之间的关系被认为是双向的。在这里，我们讨论的差距，我们的知识机制的昼夜节律功能障碍的肾脏疾病。最后，我们提供了一个简短的概述，潜在的昼夜节律为基础的干预措施，可以提供肾脏疾病的好处。
The reality of life in modern times is that our internal circadian rhythms are often out of alignment with the light/dark cycle of the external environment. This is known as circadian disruption, and a wealth of epidemiological evidence shows that it is associated with an increased risk for cardiovascular disease. Cardiovascular disease remains the top cause of death in the United States, and kidney disease in particular is a tremendous public health burden that contributes to cardiovascular deaths. There is an urgent need for new treatments for kidney disease; circadian rhythm–based therapies may be of potential benefit. The goal of this Review is to summarize the existing data that demonstrate a connection between circadian rhythm disruption and renal impairment in humans. Specifically, we will focus on chronic kidney disease, lupus nephritis, hypertension, and aging. Importantly, the relationship between circadian dysfunction and pathophysiology is thought to be bidirectional. Here we discuss the gaps in our knowledge of the mechanisms underlying circadian dysfunction in diseases of the kidney. Finally, we provide a brief overview of potential circadian rhythm–based interventions that could provide benefit in renal disease.
影响因子：
4.9
作者：
Hedberg A;Mortensen ES;Rekvig OP
通讯作者：
Rekvig OP