Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects
Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects
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DOI：
10.1212/01.wnl.0000127615.15768.ae
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发表时间：
2004-06-08
期刊：
影响因子：
9.9
通讯作者：
Martino, G
中科院分区：
文献类型：
--
作者：
Lampasona, V;Franciotta, D;Martino, G
作者用高效液相放射结合法检测了87例多发性硬化(MS)患者、12例脑脊髓炎患者和47例健康人的血清抗髓鞘少突胶质细胞蛋白(MOG)、免疫球蛋白(Ig)G。检测87例MS患者和40例正常对照患者发病时的抗-MOG-IgM。低滴度抗-MOG-Ig G(小于等于5.7%)和Ig M(小于或等于8.3%)的阳性标本在所有组和亚组中的出现频率相似。结合竞争实验表明，这些抗体具有较低的亲和力。抗MOG抗体不是疾病特异性的。
The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis ( MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects. Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects. The frequency of positive samples with low titers of anti-MOG IgG (less than or equal to5.7%) and IgM (less than or equal to8.3%) was similar in all the groups and subgroups. Binding competition experiments showed that these antibodies had low affinity. Anti-MOG antibodies are not disease specific.