The relationship between libido and testosterone levels in aging men
The relationship between libido and testosterone levels in aging men
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DOI：
10.1210/jc.2005-2508
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发表时间：
2006-07-01
影响因子：
5.8
通讯作者：
McKinlay, John B.
中科院分区：
文献类型：
--
作者：
Travison, Thomas G.;Morley, John E.;McKinlay, John B.
内容：虽然我们知道血清睾酮（T）浓度与性欲有关，但社区男性中这种关系的强度还没有确定。目的：我们的目的是评估老年男性自我报告的性欲和血清T浓度之间的关联的强度和意义。设计：我们的研究是一项以社区为基础的男性健康和老龄化评估，包括三个数据收集波：基线（T1，1987-1989年）和后续行动（T2，1995-1997年; T3，2002-2004年）。性欲采用14分量表进行测量，评估自我报告的欲望和想法/幻想的频率;性欲低下定义为得分低于7/14。设置：我们在马萨诸塞州的大波士顿进行了一项流行病学研究。参与者：基线时有1632名40-70岁的男性，随访9年（T2）时有922名（56%），随访15年（T3）时有623名（38%）。318例（19%）受试者在基线时报告性欲低下。力比多和T表现出显着的关联。然而，性欲低下的受试者和性欲正常的受试者之间的平均T水平差异很小;分析表明，性欲每增加一个单位，总T增加3.4 ng/dl（0.12 nmol/L）。报告性欲低下的受试者表现出低T的可能性增加，但不高。除以雄激素受体基因胞嘧啶，腺嘌呤，鸟嘌呤重复的数量T浓度没有增强associations.Conclusions：性欲和T浓度在人口水平上有很强的相关性。然而，个体患者报告性欲下降作为低T水平指标的价值值得商榷。
Context: Although it is known that serum testosterone ( T) concentrations are related to libido, the strength of that relationship in community-dwelling men has not yet been determined.Objective: Our objective was to assess the strength and significance of the association between aging men's self-reports of libido and serum T concentrations.Design: Our study was a community-based evaluation of men's health and aging, including three data collection waves: baseline (T1, 1987-1989) and follow-ups (T2, 1995-1997; T3, 2002-2004). Libido was measured on a 14-point scale assessing self-reported frequency of desire and thoughts/fantasies; low libido was defined as a score of less than 7 of 14.Setting: We conducted an epidemiological study in greater Boston, Massachusetts.Participants: There were 1632 men aged 40-70 yr at baseline, with follow-up on 922 (56%) at 9 yr (T2) and 623 (38%) at 15 yr (T3).Main Outcome Measures: We assessed total and calculated bioavailable T.Results: Three hundred eighteen (19%) subjects reported low libido at baseline. Libido and T displayed a significant association. However, the difference in mean T levels between those subjects with low libido and those without was small; analyses indicated a 3.4 ng/dl (0.12 nmol/liter) increase in total T per unit increase in libido. Subjects reporting low libido exhibited an increased but modest probability of exhibiting low T. Dividing T concentrations by the number of androgen receptor gene cytosine, adenine, guanine repeats did not enhance associations.Conclusions: Libido and T concentrations are strongly related at the population level. However, the value of individual patient reports of reduced libido as indicators of low T levels is open to question.