Local production of astrocytes in the cerebral cortex.
Local production of astrocytes in the cerebral cortex.
复制标题
DOI：
10.1016/j.neuroscience.2015.08.057
复制
发表时间：
2016-05-26
期刊：
影响因子：
3.3
通讯作者：
Jia JM
中科院分区：
文献类型：
--
作者：
Ge WP;Jia JM
星形胶质细胞是哺乳动物脑中最大的神经胶质细胞群。据报道，大脑皮层中的星形胶质细胞由四种来源产生，即放射状胶质细胞、室下区的祖细胞（SVZ祖细胞）、局部增殖胶质细胞和NG 2胶质细胞;然而，这四种细胞类型在多大程度上有助于出生后大脑皮层中星形胶质细胞的大量增加，这仍然是一个悬而未决的问题。在这里，我们总结了星形胶质细胞的所有可能的来源，并讨论了它们在出生后增加的作用。特别是，我们专注于星形胶质细胞来源于局部皮质内的增殖。
Astrocytes are the largest glial population in the mammalian brain. Astrocytes in the cerebral cortex are reportedly generated from four sources, namely radial glia, progenitors in the subventricular zone (SVZ progenitors), locally proliferating glia, and NG2 glia; it remains an open question, however, as to what extent these four cell types contribute to the substantial increase in astrocytes that occurs postnatally in the cerebral cortex. Here we summarize all possible sources of astrocytes and discuss their roles in this postnatal increase. In particular, we focus on astrocytes derived from local proliferation within the cortex.