LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH)-EXPRESSING CELLS DO NOT MIGRATE NORMALLY IN AN INHERITED HYPOGONADAL (KALLMANN) SYNDROME
LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH)-EXPRESSING CELLS DO NOT MIGRATE NORMALLY IN AN INHERITED HYPOGONADAL (KALLMANN) SYNDROME
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DOI：
10.1016/0169-328x(89)90076-4
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发表时间：
1989-12-01
期刊：
影响因子：
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通讯作者：
PFAFF, DW
中科院分区：
文献类型：
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作者：
SCHWANZELFUKUDA, M;BICK, D;PFAFF, DW
Kallmann综合征遗传性低促性腺激素性腺功能减退伴嗅觉丧失，与X染色体Xp 22.3缺失有关。在Kallman胎儿中，我们发现大脑中缺乏促黄体生成素释放激素（LHRH）表达细胞，尽管鼻子中有密集的LHRH细胞和纤维。含LHRH的细胞和神经突在前脑下、脑膜的硬脑膜层内、筛骨筛板的背侧表面上以缠结结束。正常胎儿的大脑，年龄和性别相匹配，LHRH细胞和纤维，如预期的那样，在下丘脑和视前区。由于最近发现LHRH表达细胞从嗅基板迁移到大脑中，因此Kallmann综合征的促性腺功能减退似乎可以由LHRH细胞迁移到大脑中的失败来解释。
Kallmann syndrome inherited hypogonadotropic hypogonadism with anosmia, is associated with an X-chromosome deletion at Xp 22.3. In a Kallman fetus, we have found an absence of luteinizing hormone-releasing hormone (LHRH)-expressing cells in the brain despite dense clusters of LHRH cells and fibers in the nose. LHRH-containing cells and neurites end in a tangle beneath the forebrain, within the dural layers of the meninges, on the dorsal surface of the cribriform plate of the ethmoid bone. Normal fetal brains, matched for age and sex, had LHRH cells and fibers, as expected, in the hypothalamus and preoptic area. Since LHRH-expressing cells recently were discovered to migrate from the olfactory placode into the brain, it appears that the hypogonadotropism of the Kallmann syndrome can be accounted for by a failure of LHRH cells to migrate into the brain.