Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance
Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance
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DOI：
10.1007/978-3-642-74095-4_1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
H. Nikaido
中科院分区：
文献类型：
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作者：
H. Nikaido
近年来，抗生素的广泛使用在对抗由“经典”致病菌引起的感染方面非常有效，但同时也导致了感染的增加，通常是医院获得性的，由具有中度甚至边缘致病性的耐药性革兰氏阴性菌引起的感染（McGowan 1985）。在这些革兰氏阴性细菌中经常遇到的对抗生素的一般抗性主要是由于这些生物体表面上存在额外的膜层：这些细菌的外膜充当有效的渗透屏障并阻止抗生素分子流入细菌细胞。
The extensive use of antibiotics in recent years has been very effective in combating infections caused by “classical” pathogenic bacteria, but at the same time it produced an increase in infections, often hospital-acquired, by antibiotic-resistant gram-negative bacteria of moderate or even marginal pathogenicity (McGowan1985). The general resistance to antibiotics, often encountered in such gram-negative bacteria, is largely due to the presence of an extra membrane layer on the surface of these organisms: the outer membrane of these bacteria acts as an effective permeation barrier and retards the influx of antibiotic molecules into the bacterial cell.