A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application.
A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical Application.
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DOI：
10.1016/j.chembiol.2015.12.003
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发表时间：
2016-01-21
影响因子：
8.6
通讯作者：
Bogyo M
中科院分区：
文献类型：
--
作者：
Garland M;Yim JJ;Bogyo M
精密医学倡议旨在利用基础和临床研究的进展来开发选择性靶向并杀死癌细胞的疗法。在同样的精确医学理论下，同样重要的是需要对这些病变细胞进行可视化，以便于诊断、促进手术切除和监测治疗反应。因此，化学家有很大的机会开发化学上容易处理的探针，可以在体内对癌症进行成像。本文综述了光学探针的最新研究进展及其在癌症临床治疗中的应用现状和前景。这里描述的探头开发的进展表明，光学成像是一个重要且快速发展的研究领域，它鼓励化学家、生物学家和临床医生之间继续合作，进一步完善这些工具，用于介入手术成像以及诊断和治疗应用。
The Precision Medicine Initiative aims to use advances in basic and clinical research to develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of precision medicine, there is an equally important need to visualize these diseased cells to enable diagnosis, facilitate surgical resection and monitor therapeutic response. Therefore, there is a great opportunity for chemists to develop chemically tractable probes that can image cancer in vivo. This review focuses on recent advances in the development of optical probes as well as their current and future applications in the clinical management of cancer. The progress in probe development described here suggests that optical imaging is an important and rapidly developing field of study that encourages continued collaboration between chemists, biologists and clinicians to further refine these tools for interventional surgical imaging, as well as for diagnostic and therapeutic applications.