How to determine the number of inner-sphere water molecules in lanthanide(III) complexes by 17O NMR spectroscopy.: A technical note
How to determine the number of inner-sphere water molecules in lanthanide(III) complexes by 17O NMR spectroscopy.: A technical note
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DOI：
10.1002/cmmi.132
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发表时间：
2007-03-01
影响因子：
--
通讯作者：
Peters, Joop. A.
中科院分区：
文献类型：
--
作者：
Djanashvili, Kristina;Peters, Joop. A.
聚氨基羧酸盐的镧系元素（III）络合物广泛用于MRI中作为造影剂。金属离子的顺磁性有助于增加H-1弛豫速率，而螯合物提供了与金属的稳定结合。直接与Ln（III）离子配位的水分子的数量对于弛豫率以及这些造影剂的功效非常重要。在这里，我们描述了方便的方法来确定这个参数的测量Ln（III）引起的水O-17 NMR共振的位移。版权所有（c）2007约翰威利父子有限公司。
Lanthanide(III) complexes of polyaminocarboxylates are widely used in MRI as contrast agents. The paramagnetic properties of the metal ion contribute to the increase of H-1 relaxation rates, while the chelate offers a stable binding with the metal. The number of water molecules, coordinated directly to the Ln(III) ion, is very important for the relaxivity and, thus, the efficacy of these contrast agents. Here, we describe convenient methods to determine this parameter by measurement of Ln(III)-induced shifts of the water O-17 NMR resonance. Copyright (c) 2007 John Wiley & Sons, Ltd.