Association analysis of the HLA-C gene in Japanese alopecia areata-猫眼课题宝

DOI：

10.1007/s00251-013-0703-z

发表时间：

2013-04

期刊：

Immunogenetics

影响因子：

3.2

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

Yuko Haida;S. Ikeda;A. Takagi;Etsuko Komiyama;T. Mabuchi;A. Ozawa;J. Kulski;H. Inoko;A. Oka

斑秃（AA）是一种器官特异性和细胞介导的自身免疫性疾病，涉及脱发，但其发病机制仍然知之甚少。许多自身免疫性疾病在遗传上与主要组织相容性复合体内的人类白细胞抗原（HLA）基因的等位基因相关。AA和HLA基因之间的关联先前在一些不同的种族群体中观察到。然而，结果是不一致的，主要易感性HLA基因和/或区域尚未被分配为AA。本研究的目的是评估与中国汉族人AA密切相关的HLA-Clocus等位基因HLA-C*07：04是否可以在日本人群中复制。采用SSO法对156例AA患者和560例健康对照者进行HLA-Clocus基因分型。经Bonferroni校正后，在检测到的17个等位基因中，只有两个等位基因C*04：01（OR = 2.25，CI 95%= 1.35- 3.75，P = 1.84E-03）和C *15：02（OR = 2.52，CI 95%= 1.37- 4.64，P = 2.90E-03）与AA显著相关。分层分析表明，C *04：01、C*07：02和C *15：02在各亚表型中代表不同的AA遗传危险因素。

Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease involving hair loss, but its pathogenesis remains poorly understood. Many autoimmune diseases are genetically associated with alleles of the human leukocyte antigen (HLA) genes within the major histocompatibility complex. Associations between AA and HLA genes were previously observed in some different ethnic groups. However, the results were inconsistent, and a primary susceptibility HLA gene and/or region has not yet been assigned for AA. The aim of this study was to evaluate whether an allele of theHLA-Clocus,HLA-C*07:04, which was strongly associated with AA in Chinese Hans, could be replicated in the Japanese population. TheHLA-Clocus was genotyped by the SSO method using 156 AA patients and 560 healthy controls. As a consequence, among the 17 alleles detected, only two alleles,C*04:01(OR = 2.25, CI 95 % = 1.35–3.75,P= 1.84E-03) andC*15:02(OR = 2.52, CI 95 % = 1.37–4.64,P= 2.90E-03), were significantly associated with AA after Bonferroni correction. Further, the stratification analysis suggested thatC*04:01,C*07:02, andC*15:02represented different AA genetic risk factors in each sub-phenotype.

Association analysis of the HLA-C gene in Japanese alopecia areata

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