Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden
Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden
复制标题
DOI：
10.1111/j.1365-2133.2011.10272.x
复制
发表时间：
2011-06-01
影响因子：
10.3
通讯作者：
Nyberg, F.
中科院分区：
文献类型：
--
作者：
Gronhagen, C. M.;Fored, C. M.;Nyberg, F.
化脓性汗腺炎（HS）的发病机制尚不清楚，治疗困难，需要有效的治疗。虽然它是不知道是否在HS皮肤的肿瘤坏死因子（TNF）-α的水平是异常的，抗TNF-α生物制剂的使用，与变量的临床effictiveness.ObjectivesTo确定在病变和perilesional HS skin.MethodsWe培养的细胞因子档案20病变和10个正常出现perilesional HS皮肤样本，7银屑病和6个健康对照皮肤样本在transwell培养系统。使用两种不同的细胞因子珠阵列来测量培养上清液中的炎性细胞因子谱。HS皮肤样本的结果进行了比较与健康和银屑病skin.ResultsThe促炎细胞因子白细胞介素（IL）-1 β和TNF-α，以及抗炎细胞因子IL-10显着升高HS皮肤。这些细胞因子的水平升高，也发现在病变周围HS皮肤。HS中IL-1 β、TNF-α和IL-10相对于对照皮肤的增加倍数分别为31、5和34，而银屑病分别为4、1和2。所有三种细胞因子的水平显示出与疾病严重程度正相关的趋势。IL-2，IL-4，IL-5和干扰素-γ几乎检测不到HS或健康对照skin.ConclusionsThis研究首次表明，IL-1 β，TNF-α和IL-10水平升高HS皮肤。这些数据为靶向细胞因子（如TNF-α和IL-1）的生物制剂治疗提供了依据。
P>BackgroundThe pathogenesis of hidradenitis suppurativa (HS) is largely unknown and the disease is difficult to treat. Patients are in high need of an effective treatment. Although it is not known whether the levels of tumour necrosis factor (TNF)-alpha are aberrant in HS skin, anti-TNF-alpha biologics are used, with variable clinical efficacy.ObjectivesTo determine the cytokine profile in lesional and perilesional HS skin.MethodsWe cultured 20 lesional and 10 normal-appearing perilesional HS skin samples, seven psoriasis and six healthy control skin samples in a transwell culture system. Two distinct cytokine bead arrays were used to measure the spectrum of inflammatory cytokines in the culture supernatant. Results from HS skin samples were compared with those of healthy and psoriasis skin.ResultsThe proinflammatory cytokines interleukin (IL)-1 beta and TNF-alpha as well as the anti-inflammatory cytokine IL-10 were significantly elevated in HS skin. Elevated levels of these cytokines were also found in perilesional HS skin. Fold increases relative to control skin of IL-1 beta, TNF-alpha and IL-10 in HS were 31, 5 and 34, compared with psoriasis: 4, 1 and 2, respectively. Levels of all three cytokines showed a trend towards a positive correlation with disease severity. IL-2, IL-4, IL-5 and interferon-gamma were hardly detectable in HS or healthy control skin.ConclusionsThis study shows for the first time that IL-1 beta, TNF-alpha and IL-10 levels are elevated in HS skin. These data provide a rationale for therapies with biologics targeting cytokines such as TNF-alpha and IL-1.