Neutrophil-to-lymphocyte ratio is not a predictor of liver histology in patients with nonalcoholic fatty liver disease
Neutrophil-to-lymphocyte ratio is not a predictor of liver histology in patients with nonalcoholic fatty liver disease
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DOI：
10.1097/meg.0000000000000405
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发表时间：
2015-10-01
影响因子：
2.1
通讯作者：
Sonmez, Alper
中科院分区：
文献类型：
--
作者：
Kara, Muammer;Dogru, Teoman;Sonmez, Alper
目的报道中性粒细胞与淋巴细胞比值（NLR）相对容易测量，可作为临床病理的一项有价值的指标。本研究的目的是探讨非酒精性脂肪性肝病（NAFLD）患者NLR与肝脏组织学表现之间的关系。设计和方法共纳入226例连续活检证实的NAFLD患者[非酒精性脂肪性肝炎（NASH, n=105）、边缘性NASH （n=74）和单纯性脂肪变性（n=47）]。采用NAFLD临床研究网络标准对NASH和纤维化进行组织学诊断。结果两组间天冬氨酸转氨酶(P
ObjectivesIt has been reported that the neutrophil-to-lymphocyte ratio (NLR) can be measured relatively easily and can serve as a valuable index for much clinical pathology. The aim of this study was to investigate the association between NLR and hepatic histological findings in patients with nonalcoholic fatty liver disease (NAFLD).Design and methodsA total of 226 consecutive patients with biopsy-proven NAFLD [nonalcoholic steatohepatitis (NASH, n=105), borderline-NASH (n=74), and simple steatosis (n=47)] were enrolled. NASH and fibrosis were diagnosed histologically using the NAFLD Clinical Research Network criteria.ResultsSignificant differences were found in aspartate aminotransferase (P