Image Scaling Difference Between a Confocal Scanning Laser Ophthalmoscope and a Flash Fundus Camera
Image Scaling Difference Between a Confocal Scanning Laser Ophthalmoscope and a Flash Fundus Camera
复制标题
DOI：
10.3928/23258160-20150909-13
复制
发表时间：
2015-09-01
影响因子：
1
通讯作者：
Sadda, Srinivas R.
中科院分区：
文献类型：
--
作者：
Nittala, Muneeswar G.;Hariri, Amirhossein;Sadda, Srinivas R.
背景与目的：为了评估闪光灯和扫描激光眼底images.Patients和方法之间的缩放和测量差异：作者分析了年龄相关性黄斑变性继发地图状萎缩患者的眼底自发荧光图像，这些患者使用30（sic）共焦扫描激光检眼镜（cSLO）和50（sic）闪光眼底照相机（FFC）成像。结果：cSLO和FFC图像（通过GRADOR）水平维度的平均（+/- SD;范围）比例因子为1.217（+/- 0.0487; 1.0474-1.272），垂直维度为1.138（+/- 0.0311; 1.0841-1.193）。水平和垂直比例因子之间的平均百分比差异为7.48（+/- 2.29; 2.30-10.70）。屈光不正（焦点）和孔径大小（或视野的图像）呈正相关，纵横比呈负相关，与地标对measurement.CONCLUSION：眼底自发荧光成像系统之间的固有图像缩放差异不限于简单的像素到毫米的校准方差，但出现不同的测量方向。当比较使用不同成像系统获得的测量值时，应考虑差异，特别是对于临床试验。
BACKGROUND AND OBJECTIVE: To evaluate scaling and measurement differences between flash and scanning laser fundus images.PATIENTS AND METHODS: The authors analyzed fundus autofluorescence images of patients with geographic atrophy secondary to age-related macular degeneration imaged with both 30(sic) confocal scanning laser ophthalmoscope (cSLO) and 50(sic) flash fundus camera (FFC). Multiple vessel-crossing points served as landmarks.RESULTS: The mean (+/- SD; range) scaling factor between cSLO and FFC images (by GRADOR) for the horizontal dimension was 1.217 (+/- 0.0487; 1.0474-1.272) versus 1.138 (+/- 0.0311; 1.0841-1.193) for the vertical dimension. The mean percentage difference between horizontal and vertical scaling factors was 7.48 (+/- 2.29; 2.30-10.70). Refractive error (focus) and aperture size (or field of view of the image) were positively correlated and aspect ratio was negatively correlated with landmark pair measurements.CONCLUSION: Inherent image-scaling differences between fundus autofluorescence imaging systems are not restricted to simple pixel-to-millimeter calibration variances, but appear to vary depending on measurement orientation. Differences should be considered when comparing measurements obtained using different imaging systems, particularly for clinical trials.