A forward-imaging needle-type OCT probe for image guided stereotactic procedures.
A forward-imaging needle-type OCT probe for image guided stereotactic procedures.
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DOI：
10.1364/oe.19.026283
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发表时间：
2011-12-19
期刊：
影响因子：
3.8
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Liang CP;Wierwille J;Moreira T;Schwartzbauer G;Jafri MS;Tang CM;Chen Y
具有多普勒光学相干断层扫描（DOCT）功能的前向成像针型光学相干断层扫描（OCT）探头有可能解决介入手术中的关键挑战。一个恰当的例子是立体定向神经外科手术，其中探针基于预定的坐标被推进到大脑中。在推进探针前方的血管撕裂是当前方法不可避免的并发症。此外，手术期间的脑脊髓液（CSF）泄漏可能使大脑移位，从而使预定坐标不可靠。为了应对这些挑战，我们开发了前向成像OCT探头（740 μm O.D.）使用梯度折射率（GRIN）棒透镜，可提供实时成像反馈，以避开风险血管（OCT/DOCT双成像，8帧/秒，每帧1024次A扫描），并以12 μm轴向分辨率（仅OCT成像，100帧/秒，每帧160次A扫描）将器械引导至特定目标。DOCT的高信号-背景特性在真实的时间内检测和量化绵羊脑实质内的血流方面提供了异常的灵敏度。OCT/DOCT双重成像也证明了其区分大鼠股血管上的血管类型（动脉/静脉）的能力。我们还证明了在离体人脑中，可以从OCT图像中的显微解剖标志推断OCT探头尖端的位置。这些发现证明了脑立体定向手术期间OCT引导的适用性及其降低脑出血风险的潜力。
A forward-imaging needle-type optical coherence tomography (OCT) probe with Doppler OCT (DOCT) capability has the potential to solve critical challenges in interventional procedures. A case in point is stereotactic neurosurgery where probes are advanced into the brain based on predetermined coordinates. Laceration of blood vessels in front of the advancing probe is an unavoidable complication with current methods. Moreover, cerebrospinal fluid (CSF) leakage during surgery can shift the brain rendering the predetermined coordinates unreliable. In order to address these challenges, we developed a forward-imaging OCT probe (740 μm O.D.) using a gradient-index (GRIN) rod lens that can provide real-time imaging feedback for avoiding at-risk vessels (8 frames/s with 1024 A-scans per frame for OCT/DOCT dual imaging) and guiding the instrument to specific targets with 12 μm axial resolution (100 frames/s with 160 A-scans per frame for OCT imaging only). The high signal-to-background characteristic of DOCT provides exceptional sensitivity in detecting and quantifying the blood flow within the sheep brain parenchyma in real time. The OCT/DOCT dual imaging also demonstrated its capability to differentiate the vessel type (artery/vein) on rat’s femoral vessels. We also demonstrated in ex vivo human brain that the location of the tip of the OCT probe can be inferred from micro-anatomical landmarks in OCT images. These findings demonstrate the suitability of OCT guidance during stereotactic procedures in the brain and its potential for reducing the risk of cerebral hemorrhage.