Fn-type chicory inulin hydrolysate has a prebiotic effect in humans
Fn-type chicory inulin hydrolysate has a prebiotic effect in humans
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DOI：
10.1093/jn/130.5.1197
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发表时间：
2000-05-01
影响因子：
4.2
通讯作者：
Roberfroid, M
中科院分区：
文献类型：
--
作者：
Menne, E;Guggenbuhl, N;Roberfroid, M
菊苣菊粉(GFn；2小于等于n小于或等于60)的部分酶解产生由GFn型和Fn型两种低聚糖组成的低聚果糖制剂(2小于或等于n小于或等于7；2小于或等于m小于或等于7)，其中G是葡萄糖，F是果糖，n是β(2-GT；1)结合果糖的数目。人类研究表明，喂养GFN型低聚物显着改变了粪便微生物区系的组成，特别是通过增加双歧杆菌的数量。这里报道的实验是用来检验FN型分子具有相同性质的假设。在一项受控喂养研究中，8名志愿者(5名女性和3名男性)每天摄入8g/d富含FN的产品，最长达5wk。采集粪便样本并进行总厌氧菌、双歧杆菌、乳杆菌、类杆菌、大肠菌群和产气荚膜梭菌的分析。2wk和5wk的低聚果糖均导致双歧杆菌数量的选择性增加(P<；0.01)。此外，每天摄入8g的FN型低聚果糖制剂可以降低粪便pH值，并几乎不会引起肠道不适。
The partial enzymatic hydrolysis of chicory inulin (GFn; 2 less than or equal to n less than or equal to 60) yields an oligofructose preparation that is composed of both GFn-type and Fn-type oligosaccharides (2 less than or equal to n less than or equal to 7; 2 less than or equal to m less than or equal to 7), where G is glucose, F is fructose, and n is the number of beta(2-->1) bound fructose moieties. Human studies have shown that feeding GFn-type oligomers significantly modifies the composition of the fecal microflora especially by increasing the number of bifidobacteria. The experiments reported here were used to test the hypothesis that the Fn-type molecules have the same property. During a controlled feeding study, 8 volunteers (5 females and 3 males) consumed 8 g/d of an Fn-rich product for up to 5 wk. Fecal samples were collected and analyzed for total anaerobes, bifidobacteria, lactobacilli, bacteroides, coliforms and Clostridium perfringens. Both 2 and 5 wk of oligofructose feeding resulted in a selective increase in bifidobacteria (P < 0.01). In addition, a daily intake of 8 g of the Fn-type oligofructose preparation reduced fecal pH and caused little intestinal discomfort.