Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
复制标题
亚洲精神分裂症患者的大麻使用与攻击行为和长效注射抗精神病药物治疗相关
DOI：
10.1080/08039488.2019.1632381
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发表时间：
2019
影响因子：
1.8
通讯作者：
Y-C Park
中科院分区：
文献类型：
--
作者：
S-C Park;H-S Oh;A Tripathi;R-A Kallivayalil;A Avasthi;S Grover;A-J Tanra;S Kanba;T-A Kato;T Inada;K-Y Chee;M-Y Chong;S-K Lin;K Sim;Y-T Xiang;C-H Tan;A Javed;N Sartorius;N Shinfuku;Y-C Park
背景：虽然大麻的使用与精神分裂症的剂量反应模式，据我们所知，大麻和精神分裂症之间的关系很少被报道在亚洲population.Aim：我们比较了亚洲精神分裂症患者大麻使用者和非使用者之间的临床特征和精神药物处方模式。此外，我们的目的是确定这些subjects.Methods的大麻使用的独立相关性：我们进行了分析的数据，从亚洲精神药物抗精神病药物的处方模式的研究（REAP-AP），一个合作的财团调查，用于整理抗精神病药物和其他精神药物的处方模式在亚洲精神分裂症患者。我们将132名精神分裂症患者纳入终身使用大麻的组中，将1756名从未使用过大麻的患者纳入组中。二进制逻辑模型拟合检测终身大麻use.Results的临床相关性：调整年龄，性别，地理区域，收入组，未治疗的精神病的持续时间，和Charlson共病指数水平的影响，二进制逻辑回归模型显示，终身大麻的使用是独立相关的攻击行为[调整后的比值比（aOR）= 1.582，95%置信区间（CI）= 1.006- 2.490，p = 0.047]和长效注射抗精神病药物治疗（aOR = 1.796，95%CI = 1.444- 2.820，p = 0.001）。结论：我们的研究结果表明，终身大麻使用和攻击行为之间的密切联系。在亚洲，特别是南亚或东南亚，使用长效注射型抗精神病药物优先治疗精神分裂症患者中的攻击行为大麻使用者。
Background:Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population.Aim:We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects.Methods:We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use.Results:Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95% confidence interval (CI) = 1.006–2.490,p= .047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95% CI = 1.444–2.820,p= .001).Conclusion:Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.