EFFECT OF HIGH-DOSES OF HUMAN RECOMBINANT ERYTHROPOIETIN ON THE NEED FOR BLOOD-TRANSFUSIONS IN PRETERM INFANTS
EFFECT OF HIGH-DOSES OF HUMAN RECOMBINANT ERYTHROPOIETIN ON THE NEED FOR BLOOD-TRANSFUSIONS IN PRETERM INFANTS
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DOI：
10.1016/s0022-3476(05)82552-1
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发表时间：
1992-07-01
影响因子：
5.1
通讯作者：
CANTARUTTI, F
中科院分区：
文献类型：
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作者：
CARNIELLI, V;MONTINI, G;CANTARUTTI, F
为了确定使用重组人促红细胞生成素(RHuEPO)和铁预防治疗是否可以减少输血需求，我们随机将22名胎龄小于或等于32周、出生体重小于或等于1.75公斤的早产儿分为两组，从出生第二天开始，给予rHuEPO 400IU/kg，每周三次，外加铁20 mg/wk静脉注射，或不使用rHuEPO和不使用铁(11例)。两组的出生体重和临床变量相似。接受治疗的婴儿需要输血(0.8+/-1.5vs3.1+/-2.1；p=0.01)和红细胞压积(14.2+/-25.9vs48.4+/-34.0ml/kg；p=0.02)。采血量无差异(19.5+/-21.1对27.8+/-19.1毫升/公斤；p=0.35)。治疗组网织红细胞和红细胞压积分别为4.46%+/-0.8%比1.49%+/-1.1%(p=0.0001)和48.1%+/-7.3%比43.8%+/-4.7%(p=0.004)。没有发现rHuEPO或静脉注射铁的副作用。这些数据表明，rHuEPO联合补铁有效地减少了早产儿输血的需要。需要更多关于剂量、时机以及铁和维生素补充剂的信息。
To determine whether prophylactic treatment with recombinant human erythropoietin (rHuEPO) and iron would reduce the need for blood transfusions, we randomly assigned 22 premature infants with gestational ages less-than-or-equal-to 32 weeks and birth weights less-than-or-equal-to 1.75 kg to receive rHuEPO, 400 IU/kg three times a week, plus iron, 20 mg/wk intravenously, from the second day of life (11 infants), or no rHuEPO and no iron (11 infants). The two groups had similar birth weights and clinical variables. The treated infants required fewer blood transfusions (0.8 +/- 1.5 vs 3.1 +/- 2.1; p = 0.01) and less volume of packed erythrocytes (14.2 +/- 25.9 vs 48.4 +/- 34.0 ml/kg; p = 0.02). The amounts of blood sampled were not different (19.5 +/- 21.1 vs 27.8 +/- 19.1 ml/kg; p = 0.35). Reticulocyte and hematocrit values were higher in the treated group (4.46% +/- 0.8% vs 1.49% +/- 1.1% (p = 0.0001) and 48.1% +/- 7.3% vs 43.8% +/- 4.7% (p = 0.004), respectively). No side effects of either rHuEPO or intravenously administered iron were noted. These data indicate that rHuEPO, in combination with iron supplementation, is effective in reducing the need for blood transfusions in the premature infant. More information is needed on dosage, timing, and iron and vitamin supplementation.