Promoter polymorphism in the matrix metalloproteinase-1 and risk of cervical cancer in Korean women.
Promoter polymorphism in the matrix metalloproteinase-1 and risk of cervical cancer in Korean women.
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基质金属蛋白酶-1 启动子多态性与韩国女性宫颈癌风险。
DOI：
10.1016/j.canlet.2004.08.032
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发表时间：
2005
期刊：
影响因子：
9.7
通讯作者：
H. Lee
中科院分区：
文献类型：
--
作者：
W. Ju;Sokbom Kang;J. W. Kim;N. Park;Y. Song;Soon;H. Lee
本研究的目的是分析基质金属蛋白酶-1启动子基因−1607bp区域单核苷酸多态性与韩国女性宫颈癌风险的关系。收集了1999年至2002年在首尔国立大学医院就诊的232例宫颈癌患者和332例非肿瘤对照受试者的血液样本。采用TaqMan法检测基质金属蛋白酶-1基因启动子−-1607区域的多态性。比较宫颈癌组和对照组的等位基因频率和基因型分布，以确定该基因多态性是否增加了韩国妇女患宫颈癌的易感性。通过对癌组织FIGO分期、淋巴结状态、组织学类型、宫旁侵犯等临床病理资料的整理，评价该SNP与肿瘤侵袭性的关系。宫颈癌组2G等位基因频率为66.1%，对照组为68.2%，差异无统计学意义(P=0.41)。同样，具有插入(2G/2G)或缺失(1G/1G)多态的基因型与1G/2G基因型相比没有增加患宫颈癌的风险。亚组间临床病理参数分析亦无显着性差异，提示MMP1启动子−1607bp的单核苷酸多态与宫颈癌侵袭性无关。综上所述，这项研究表明，具有特定MMP1基因多态性的韩国人既不更容易患宫颈癌，也不更容易发生癌症进展。
The aim of this investigation was to analyze the association between a single nucleotide polymorphism (SNP) in the matrix metalloproteinase (MMP)-1 promoter gene −1607bp region and cervical cancer risk in Korean women. The blood samples of 232 cervical cancer patients and 332 non-cancer control subjects who managed at Seoul National University Hospital from 1999 to 2002 were collected. Polymorphism in MMP-1 promoter −1607 region was determined using TaqMan method. Allele frequency and genotype distribution in the cervical cancer group were compared with those of the control group to determine whether this polymorphism elevates the susceptibility of Korean women to cervical cancer. The relationship between this SNP and cancer invasiveness was also evaluated by collating clinicopathologic data of those in the cancer group, such as FIGO stage, lymph node status, histologic type and parametrial invasion. In the cervical cancer group, the allele frequency of 2G was 66.1%, in the control group 68.2%, showing no significant difference (P=0.41). Similarly the genotypes with insertion (2G/2G) or deletion (1G/1G) polymorphism showed no increased risk for cervical cancer susceptibility compared with 1G/2G genotype. A subgroup analysis of the clinicopathologic parameters in cancer group also showed no significant difference suggesting the lack of an association between SNP of the MMP-1 promoter −1607bp region and cervical cancer invasiveness. In conclusion, this study shows that Korean with specific polymorphism in MMP-1 are neither more susceptible to develop cervical cancer nor more vulnerable for cancer progression.