Molecular interactions continuously define the organizer during the cell movements of gastrulation
Molecular interactions continuously define the organizer during the cell movements of gastrulation
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DOI：
10.1016/s0092-8674(00)80044-6
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发表时间：
1999-09-03
期刊：
影响因子：
64.5
通讯作者：
Stern, CD
中科院分区：
文献类型：
--
作者：
Joubin, K;Stern, CD
组织者是原肠胚胎中一个独特的区域，它诱导和形成体轴。在Nieuwkoop中心的影响下，它发生在原肠形成之前。我们发现，在原肠发育过程中，细胞运动将细胞带进和带出雏鸟组织者--亨森结节。在这些运动中，细胞根据它们的位置获得和失去组织者属性。一个“节点诱导中心”位于原始条纹的中央，它发出Vg1和WNT8C。它的活性被节点产生的ADMP和外围的BMP所抑制。这些相互作用将组织者定义为胚胎中的一个位置，其细胞组成不断变化，并解释了组织者再生的现象。
The organizer is a unique region in the gastrulating embryo that induces and patterns the body axis. It arises before gastrulation under the influence of the Nieuwkoop center. We show that during gastrulation, cell movements bring cells into and out of the chick organizer, Hensen's node. During these movements, cells acquire and lose organizer properties according to their position. A "node inducing center," which emits Vg1 and Wnt8C, is located in the middle of the primitive streak. Its activity is inhibited by ADMP produced by the node and by BMPs at the periphery. These interactions define the organizer as a position in the embryo, whose cellular makeup is constantly changing, and explain the phenomenon of organizer regeneration.