High levels of donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation
High levels of donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation
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DOI：
10.1111/j.1600-6143.2008.02240.x
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发表时间：
2008-06-01
影响因子：
8.8
通讯作者：
Piemonti, L.
中科院分区：
文献类型：
--
作者：
Ogliari, A. C.;Caldara, R.;Piemonti, L.
在本研究中，我们分析了趋化因子家族成员 CCL2 在早期移植物损伤中的作用。使用同时肾胰移植（SPK）作为模型，我们发现脑死亡显着增加了人类循环中的 CCL2 水平。我们发现，在这种情况下，供体 CCL2 水平较高（在器官恢复前和冷保存开始时测量）与移植后一周内移植物和受体再灌注后释放的 CCL2 增加相关 (n = 28)。在一项对 77 名 SPK 受者的回顾性研究中，我们发现供体高水平的 CCL2 与移植物存活率之间存在显着的负相关。这些患者的生存率下降与早期移植后并发症有关，包括胰腺血栓形成和肾功能延迟的发生率较高。综上所述，我们的数据表明，供体血清中的高 CCL2 水平预示着移植物/受体 CCL2 产量的增加和移植物存活率的下降。这表明脑死亡引起的炎症反应的严重程度影响移植后炎症反应，与随后的缺血和再灌注无关。
In this study we analyzed the role of CCL2, a member of the chemokine family, in early graft damage. Using simultaneous kidney-pancreas transplantation (SPK) as a model, we showed that brain death significantly increases circulating CCL2 levels in humans. We found that in such situations, high donor CCL2 levels (measured before organ recovery and at the onset of cold preservation) correlate with increased postreperfusion release of CCL2 by both the graft and recipient throughout the week following transplantation (n = 28). In a retrospective study of 77 SPK recipients, we found a significant negative association between high donor levels of CCL2 and graft survival. Decreased survival in these patients is related to early posttransplant complications, including a higher incidence of pancreas thrombosis and delayed kidney function. Taken together our data indicate that high CCL2 levels in the donor serum predict both an increase in graft/recipient CCL2 production and poor graft survival. This suggests that the severity of the inflammatory response induced by brain death influences the posttransplant inflammatory response, independent of subsequent ischemia and reperfusion.