RARRES1 expression is significantly related to tumor differentiation and staging in colorectal adenocarcinoma
RARRES1 expression is significantly related to tumor differentiation and staging in colorectal adenocarcinoma
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DOI：
10.1016/j.ejca.2005.11.015
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发表时间：
2006-03-01
影响因子：
8.4
通讯作者：
Jiang, SY
中科院分区：
文献类型：
--
作者：
Wu, CC;Shyu, RY;Jiang, SY
视黄酸受体应答基因1（RARRES 1）是一个视黄酸调节基因。在几种类型的恶性组织中，它的表达经常通过DNA超甲基化而下调。本研究采用免疫组化方法检测161例（26例腺瘤、13例远端正常黏膜和122例原发性结直肠腺癌）结直肠石蜡标本中RARRES 1蛋白的表达及其与RARRES 3蛋白表达的相关性。RARRES1蛋白在正常粘膜组织和所有26例腺瘤组织的终末分化细胞中检测到最高水平。在122例结直肠腺癌中，低分化腺癌和Dukes'D期肿瘤显示RARRES 1表达显著降低（分别为P < 0.001和P < 0.01）。RARRES1和RARRES3的表达呈显著正相关（P < 0.001），RARRES3的表达与肿瘤分化程度呈正相关（P < 0.001）。119例患者中RARRES 1表达的差异对患者生存率没有明显影响。我们的研究结果表明RARRES 1在结直肠上皮分化中的作用，RARRES 1的下调与D期进展有关。(c)2005爱思唯尔有限公司保留所有权利。
Retinoic acid receptor responder 1 (RARRES1) is a retinoid regulated gene. Its expression is frequently down-regulated through DNA hypermethylation in several types of malignant tissues. This study investigated the clinical significance of RARRES1 protein and its association with RARRES3 protein expression in 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) paraffin-embedded colorectal tissues by immuno-histochernistry. RARRES1 protein was detected at the highest levels in terminally differentiated cells of normal mucosal tissues and all 26 adenoma tissues. Among 122 colorectal adenocarcinomas, the poorly differentiated adenocarcinomas and Dukes' stage D tumours; showed a significant decrease in RARRES1 expression (P < 0.001 and P < 0.01, respectively). RARRES1 expression was significantly (P < 0.001) correlated with RARRES3 expression, which was positively associated with tumour differentiation (P < 0.001). Difference in expression of RARRES1 among 119 patients had no apparent effect on patient survival. Our results suggest the role of RARRES1 in colorectal epithelial differentiation, and the down-regulation of RARRES1 is related to stage D progression. (c) 2005 Elsevier Ltd. All rights reserved.