Effect of Cataract and its Removal on Signal Strength and Peripapillary Retinal Nerve Fiber Layer Optical Coherence Tomography Measurements
Effect of Cataract and its Removal on Signal Strength and Peripapillary Retinal Nerve Fiber Layer Optical Coherence Tomography Measurements
复制标题
白内障及其摘除对信号强度和毛周视网膜神经纤维层光学相干断层扫描测量的影响
DOI：
10.1097/ijg.0b013e3181ccb93b
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发表时间：
2011-01-01
影响因子：
2
通讯作者：
Budenz, Donald L.
中科院分区：
文献类型：
--
作者：
Mwanza, Jean C.;Bhorade, Anjali M.;Budenz, Donald L.
目的：为了评估白内障对光学相干断层扫描（OCT），信号强度（SS）和视乳头周围视网膜神经纤维层（RNFL）厚度measurements.Methods的影响：在45例白内障患者（包括23例青光眼患者）白内障摘除术前后，使用快速RNFL厚度（3.4）采集协议，通过Stratus OCT扫描获得视乳头周围RNFL厚度测量值。根据透镜混浊分类系统III对白内障进行分级。结果：术后RNFL厚度和SS分别比术前增加9.3%（P= 0.001）和24.1%（P< 0.001）。术前RNFL测量值较低（r=-0.63，P< 0.001）和SS测量值较低（r=-0.59，P< 0.001）的患者术后RNFL厚度测量值变化较大。术前SS > 6眼白内障手术前后RNFL厚度无显著性差异（P= 0.14）。仅患白内障的眼睛（10.9 ± 20.8 mm）与患白内障和青光眼的眼睛（7.0 ± 14.7 mm; P= 0.81.Conclusions：白内障可能降低OCT扫描的视乳头周围RNFL厚度测量值和SS。提示白内障进展的视乳头周围RNFL变薄可能是由于白内障进展造成的伪影，而不是视乳头周围RNFL的实际结构变化。在患有严重白内障的昏迷眼中，应谨慎解释瞳孔周围RNFL厚度测量值，特别是如果SS减弱。
Purpose: To assess the effect of cataract on optical coherence tomography (OCT), signal strength (SS), and peripapillary retinal nerve fiber layer (RNFL) thickness measurements.Methods: Peripapillary RNFL thickness measurements were obtained by Stratus OCT scans using the Fast RNFL thickness (3.4) acquisition protocol before and after cataract extraction in 45 patients with cataract, including 23 glaucoma patients. Cataracts were graded according to the Lens Opacities Classification System III.Results: The postoperative RNFL thickness and SS were 9.3% (P= 0.001) and 24.1% (P< 0.001) higher than before surgery, respectively. There was greater postoperative change in RNFL thickness measurements in patients with lower preoperative RNFL measurements (r= - 0.63, P< 0.001) and SS (r= - 0.59, P< 0.001). Eyes with preoperative SS more than 6 had no significant difference between precataract and postcataract surgery RNFL thickness (P= 0.14). There was no significant difference in RNFL thickness change between eyes with cataract only (10.9 +/- 20.8 mm) and those with cataract and glaucoma (7.0 +/- 14.7 mm; P= 0.81).Conclusions: Cataracts may decrease peripapillary RNFL thickness measurements and the SS on OCT scans. Thinning of the peripapillary RNFL suggestive of glaucomatous progression may be the result of artifact from advancing cataract rather than actual structural changes in the peripapillary RNFL. Peripapillary RNFL thickness measurements should be interpreted with caution in glaucomatous eyes with significant cataract, particularly if the SS is attenuated.