Triple-negative breast cancer: correlation between imaging and pathological findings
Triple-negative breast cancer: correlation between imaging and pathological findings
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DOI：
10.1007/s00330-009-1656-3
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发表时间：
2010-05-01
影响因子：
5.9
通讯作者：
Lee, Sang-Ah
中科院分区：
文献类型：
--
作者：
Ko, Eun Sook;Lee, Byung Hee;Lee, Sang-Ah
本研究旨在探讨三阴性乳腺癌的钼靶X线和超声表现，并与ER阳性/PR阴性/HER 2阴性乳腺癌和ER阴性/PR阴性/HER 2阳性乳腺癌的特征进行比较，从2007年1月至2008年10月，对245例经病理证实的三阴性乳腺癌患者（n = 87）的钼靶X线和超声表现，回顾性分析了ER阳性/PR阴性/HER 2阴性（n = 93）或ER阴性/PR阴性/HER 2阳性乳腺癌（n = 65）。我们还回顾了病理报告中的组织学类型、组织学分级和生物学标志物的状态。在乳房X线摄影中，三阴性乳腺癌通常表现为肿块（43/87，49%）或局灶性不对称（19/87，22%），与钙化的相关性较低。在超声检查中，肿瘤较少被视为非肿块性病变（12/87，14%），更可能具有边界清晰的边缘（43/75，57%），明显低回声（36/75，57%），不太可能显示后方阴影（4/75，5%）。在这三种类型的乳腺癌中，ER阴性/PR阴性/HER 2阳性乳腺癌在钼靶X线检查中最常见的是伴有钙化（52/65，79%），在超声检查中最常见的是非肿块性病变（21/65，32%）。
This study was designed to investigate the mammography and ultrasound findings of triple-negative breast cancer and to compare the results with characteristics of ER-positive/PR-negative/HER2-negative breast cancer and ER-negative/PR-negative/HER2-positive breast cancer.From January 2007 to October 2008, mammography and ultrasound findings of 245 patients with pathologically confirmed triple-negative (n = 87), ER-positive/PR-negative/HER2-negative (n = 93) or ER-negative/PR-negative/HER2-positive breast cancers (n = 65) were retrospectively reviewed. We also reviewed pathological reports for information on the histological type, histological grade and the status of the biological markers.Triple-negative breast cancers showed a high histological grade. On mammography, triple-negative breast cancers usually presented with a mass (43/87, 49%) or with focal asymmetry (19/87, 22%), and were less associated with calcifications. On ultrasound, the cancers were less frequently seen as non-mass lesions (12/87, 14%), more likely to have circumscribed margins (43/75, 57%), were markedly hypoechoic (36/75, 57%) and less likely to show posterior shadowing (4/75, 5%). Among the three types of breast cancers, ER-negative/PR-negative/HER2-positive breast cancers most commonly had associated calcifications (52/65, 79%) on mammography and were depicted as non-mass lesions (21/65, 32%) on ultrasound.Our results suggest that the imaging findings might be useful in diagnosing triple-negative breast cancer.