Arterial pressure response to infused serotonin in normotensive dogs, cats, hypertensive dogs and man.
Arterial pressure response to infused serotonin in normotensive dogs, cats, hypertensive dogs and man.
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DOI：
10.1152/ajplegacy.1956.184.2.265
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发表时间：
1956-01
期刊：
影响因子：
--
通讯作者：
I. Page;J. Mccubbin
中科院分区：
文献类型：
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作者：
I. Page;J. Mccubbin
犬和猫静脉输注5-羟色胺后的动脉压反应通常是持续下降;这与单次快速注射5-羟色胺的通常反应不同，表明控制反应的机制取决于给药方式。它的结论是，当5-羟色胺注入降压反应至少有三个主要的贡献机制：a）释放内源性组胺的5-羟色胺; B）外周抑制神经源性血管收缩; c）的剂量-反应关系，在某些制剂中，决定是否动脉压的变化应是上升或下降。静脉注射5-羟色胺对3例高血压患者的反应与正常血压犬、猫或神经源性高血压犬不同。这些患者的反应是动脉压持续小幅升高。在狗身上注射组胺或血清素引起了对其他药物的类似反应：那些...
Arterial pressure response to intravenous infusion of serotonin in dogs and cats is usually a sustained fall; this differs from the usual response to a single quick injection of serotonin and suggests that the mechanisms controlling response are different depending upon the manner of administration of the drug. It is concluded that when serotonin is infused the depressor response has at least three main contributory mechanisms: a) release of endogenous histamine by serotonin; b) peripheral inhibition of neurogenic vasoconstriction; c) a dose-response relationship that, in some preparations, determines whether change in arterial pressure shall be a rise or fall. The response to intravenous infusion of serotonin in three hypertensive patients was different from that in normotensive dogs and cats or neurogenic hypertensive dogs. These patients responded with a small, sustained rise in arterial pressure. Infusion of either histamine or serotonin in dogs caused similar changes in response to other drugs: those...