CANNABINOID PENETRATION AND CHRONIC EFFECTS IN EYE
CANNABINOID PENETRATION AND CHRONIC EFFECTS IN EYE
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DOI：
10.1016/0014-4835(77)90260-3
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发表时间：
1977-01-01
影响因子：
3.4
通讯作者：
BOWMAN, K
中科院分区：
文献类型：
--
作者：
GREEN, K;BIGGER, JF;BOWMAN, K
The penetration of topically applied 14C-labeled .DELTA.9-tetrahydrocannabinol (THC) from various vehicles into the eye [rabbit] was measured, and a low viscosity light mineral oil proved to be most efficient. Further delineation of oils was made on the basis of the physiological intraocular pressure decrease in response to topical THC and the least viscous oil proved most efficacious. Both 9 and 60 day studies were made with both an oil soluble and water soluble cannabinoid related to THC. Drops were applied topically, 2 .times. 50 .mu.l/day, and the intraocular pressure response noted daily in the 9 day study and approximately once weekly in the 60 day study. The intraocular pressure always fell by about 20% at the dose levels employed here in response to the drugs and no tolerance was noted. The water soluble derivative produced a greater intraocular pressure reduction in ganglionectomized eyes.
