Dynamic miRNA-mRNA paradigms: New faces of miRNAs.
Dynamic miRNA-mRNA paradigms: New faces of miRNAs.
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DOI：
10.1016/j.bbrep.2015.10.011
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发表时间：
2015-12
影响因子：
2.7
通讯作者：
Leng XM
中科院分区：
文献类型：
--
作者：
Ni WJ;Leng XM
越来越多的证据表明，非编码RNA（non-coding RNA，ncRNA），如microRNA（microRNA，miRNAs），可以在时空上调控遗传信息的传递。虽然miRNAs的生物起源和功能已经很详细，但miRNAs和mRNAs之间的动态相互作用的阐明才刚刚开始。在这里，我们强调了可能发生在不同细胞位置的miRNA-mRNA相互作用。在动态相互作用过程中，miRNA的结合位点不仅包括3′ UTR，还包括5′ UTR和CDS。在不同的生理或病理条件下，miRNAs可以从抑制翻译转变为激活翻译。动态miRNA-mRNA范式揭示了基因调控网络的冰山一角，为其他ncRNA的功能研究提供了线索。miRNA-mRNA相互作用可能发生在不同的细胞位置。miRNA的结合位点不仅包括3′ UTR，还包括5′ UTR和CDS。miRNAs可以从翻译抑制转变为激活。
More and more evidences suggested that the flow of genetic information can be spatially and temporally regulated by non-coding RNAs (ncRNAs), such as microRNAs (miRNAs). Although biogenesis and function of miRNAs have been well detailed, elucidation of the dynamic interplays between miRNAs and mRNAs have just begun. Here, we highlighted that the miRNA–mRNA interactions which could take place in different cellular locations. During dynamic interactions, miRNA binding sites included not only 3′UTRs, but also 5′UTRs and CDSs. Under different physiological or pathological conditions, miRNAs could switch from translational inhibition to activation. Dynamic miRNA–mRNA paradigms which suggested a novel tip of the iceberg beneath the gene regulation network will provide clues for function studies of other ncRNAs. miRNA–mRNA interactions which could take place in different cellular locations. miRNA binding sites included not only 3′UTRs, but also 5′UTRs and CDSs. miRNAs could switch from translational inhibition to activation.