A multidisciplinary approach to the functional and esthetic rehabilitation of dentinogenesis imperfecta type II: A clinical report
A multidisciplinary approach to the functional and esthetic rehabilitation of dentinogenesis imperfecta type II: A clinical report
复制标题
II 型牙本质发育不全的功能和美学康复的多学科方法：临床报告
DOI：
10.1016/j.prosdent.2018.10.028
复制
发表时间：
2019-08-01
影响因子：
4.6
通讯作者：
Ma, Jianfeng
中科院分区：
文献类型：
--
作者：
Fan, Fan;Li, Ning;Ma, Jianfeng
一个20岁的女性提出了一个不美观的外观和严重磨损的前牙。采用多学科联合治疗设计了预期的治疗方案。同时，将基因测序技术应用于临床诊断，并将数字化微笑设计（DSD）应用于前牙美学设计。3个月随访显示结局可接受。对牙本质涎磷蛋白的聚合链反应产物进行了全外显子测序和直接测序，但牙本质涎磷蛋白外显子5的重复区需要进一步测序（数据未显示）。DSD协助并改善了最终修复体的美学设计、与患者的沟通以及治疗的可预测性。这种治疗表明，诊断和鉴别诊断的患者牙本质生成障碍（DGI）-II是必不可少的和有效的实施明确的治疗计划。基因筛查可作为诊断DGI-II的辅助手段。在美学设计方面，渠务署在确保令人满意的结果方面发挥了重要作用。此外，一个多学科的治疗方案，侧重于修复，这是从传统的治疗不同的DGI-II，只包括修复康复，被证明是非常有效的美学恢复与DGI-II患者。
A 20-year-old woman presented with an unesthetic appearance and severe wear of the anterior teeth. Definitive expected treatment was designed by multidisciplinary combination therapy. Meanwhile, gene sequencing was used diagnostically, and digital smile design (DSD) was used to design the esthetics of the anterior teeth. The 3-month follow-up showed an acceptable outcome. The whole-exon sequencing and direct sequencing of polymerized chain reaction products of dentin sialophosphoprotein were performed, but further sequencing was needed in the repeat region of dentin sialophosphoprotein exon 5 (the data were not shown). DSD assisted and improved the esthetic design of the definitive restoration, communication with the patient, and predictability of the treatment. This treatment demonstrates that the diagnosis and differential diagnosis of patients with dentinogenesis imperfecta (DGI)-II are essential and effective for implementing the definitive treatment plan. Gene screening can be used as an auxiliary method of diagnosing DGI-II. In terms of esthetic design, DSD played an important role in ensuring a satisfactory result. Moreover, a multidisciplinary treatment protocol focusing on prosthodontics, which is different from the traditional treatment of DGI-II and consists solely of prosthodontic rehabilitation, proved highly effective in the esthetic restoration of a patient with DGI-II.