Preventive effect of taurine on experimental type II diabetic nephropathy.
Preventive effect of taurine on experimental type II diabetic nephropathy.
复制标题
牛磺酸对实验性II型糖尿病肾病的预防作用
DOI：
10.1186/1423-0127-17-s1-s46
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发表时间：
2010-08-24
影响因子：
11
通讯作者：
Hu J
中科院分区：
文献类型：
--
作者：
Lin S;Yang J;Wu G;Liu M;Luan X;Lv Q;Zhao H;Hu J
背景牛磺酸单独使用或与其他药物合用已证实对糖尿病及其并发症有一定的预防作用，但牛磺酸预防糖尿病肾病的报道较少，其机制尚不清楚。方法对高脂高糖饮食联合STZ注射诱导的II型糖尿病大鼠给予牛磺酸。通过检测血糖、血脂代谢、肾功能及肾小球基底膜代谢来探讨牛磺酸对糖尿病肾病的预防作用。结果牛磺酸可降低糖尿病大鼠血糖、TG、TC、BUN、Scr、NAG、U-PRO、层粘连蛋白B1(LBN1)mRNA的表达,升高HDL-C。结论:牛磺酸可通过降低血糖、改善脂代谢、肾小球基底膜代谢和肾功能。
BackgroundIt has been verified that taurine has some preventive effects on diabetes and its complications when used alone or together with other drugs, but there are few reports about taurine on the prevention of diabetic nephropathy, the mechanisms of which are still unknown.MethodsTaurine was administered to type II diabetic rats induced by high fat high sugar diet combined with STZ injection. The preventive effect of taurine on diabetic nephropathy was investigated by detecting blood glucose, lipid metabolism, kidney function and glomerular basement membrane metabolism.ResultsTaurine could lower blood glucose, TG, TC, BUN, Scr, NAG, U-PRO, the expression of laminin B1( LBN1) mRNA, and increase HDL-C of diabetic rats.ConclusionsThe results indicated that taurine could prevent the occurrence and development of diabetic nephropathy by decreasing blood glucose, improving lipid metabolism, glomerular basement membrane metabolism, and kidney function.