Accumulation of a specific subset of D. melanogaster heat shock mRNAs in normal development without heat shock
Accumulation of a specific subset of D. melanogaster heat shock mRNAs in normal development without heat shock
复制标题
DOI：
10.1016/0092-8674(83)90299-4
复制
发表时间：
1983-04
期刊：
影响因子：
64.5
通讯作者：
J. Zimmerman;W. Petri;M. Meselson
中科院分区：
文献类型：
--
作者：
J. Zimmerman;W. Petri;M. Meselson
D.在黑腹果蝇中，七种热休克蛋白中的三种（hsp 83、hsp 28和hsp 26）的信使RNA在成体卵巢中积累，并且在胚胎中丰富，直到胚盘。这三种mRNA似乎起源于保育细胞，随后在第1011阶段进入卵母细胞。几乎没有，如果任何其他四个热休克mRNA存在于未休克卵巢或胚胎在任何时间检查。前胚盘胚胎不能积累这些热休克mRNA，即使受到热休克。7种热休克蛋白中只有3种的mRNA在正常卵子发生中的积累表明存在差异，可能是热休克基因表达的多重控制，并表明热休克蛋白HSP83、HSP28和HSP26在卵母细胞或早期胚胎中起作用。
During normal development in D. melanogaster, messenger RNAs for three of the seven heat shock proteins (hsp83, hsp28 and hsp26) accumulate in adult ovaries and are abundant in embryos until blastoderm. The three mRNAs appear to originate in nurse cells and subsequently pass, during stages 1 Ol 1, into the oocyte. Little if any of the four other heat shock mRNAs is present in unshocked ovaries or embryos at any time examined. Pre-blastoderm embryos fail to accumulate these heat shock mRNAs even if subjected to heat shock. The accumulation in normal oogenesis of mRNAs for only three of the seven heat shock proteins indicates the existence of differential, possibly multiple controls of heat shock gene expression, and suggests that heat shock proteins hsp83, hsp28 and hsp26 function in the oocyte or early embryo.