Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry.
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry.
复制标题
药物中含硫支架的合成及其在药物化学中的应用
DOI：
10.2174/1568026615666150915111741
复制
发表时间：
2016
影响因子：
3.4
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Feng M;Tang B;Liang SH;Jiang X
硫疗法的发展对制药工业的发展具有重要的影响。硫衍生的官能团可以在广泛的药物和天然产品中找到。几个世纪以来，硫一直保持着它作为主要杂原子的地位，被纳入FDA批准的362种含硫药物中（除了氧或氮）。磺胺类、硫醚类、砜类和青霉素类是含硫药物中最常见的支架，近几十年来在合成和应用方面都得到了很好的研究。本文综述了这四个部分在药物中的应用以及相应核心支架的合成研究进展。
The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.