A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy
A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy
复制标题
通过电荷分离工程优化的稳健窄带隙四硫化钒声敏剂，用于增强声动力癌症治疗
DOI：
10.1002/adma.202101467
复制
发表时间：
2021-07-23
影响因子：
29.4
通讯作者：
Lin, Jun
中科院分区：
文献类型：
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作者：
Liang, Shuang;Liu, Bin;Lin, Jun
提高肿瘤内活性氧（ROS）的声敏剂的开发和优化在当前声动力学治疗（SDT）中无疑是有吸引力的。鉴于此，具有较窄带隙的支链四硫化钒（VS 4）纳米枝晶（与最广泛探索的声敏剂相比）被提出作为声敏剂的新来源，其允许更轻松地分离用于ROS生成的声触发电子-空穴对。具体而言，铂（Pt）纳米颗粒和内源性高水平的谷胱甘肽（GSH）被合理设计，以进一步优化其声致敏性能。作为助催化剂，Pt有助于捕获电子，而GSH作为天然的空穴清除剂，倾向于捕获空穴。与原始VS 4声敏剂相比，GSH-Pt-VS 4纳米复合材料可以大大延长电荷的寿命，并赋予高效的ROS产生活性。此外，这种纳米平台能够重塑肿瘤微环境以实现ROS过度产生，这是通过克服肿瘤缺氧以改善SDT触发的单线态氧产生，催化内源性过氧化氢转化为破坏性羟基自由基用于化学动力学治疗，以及消耗GSH以放大肿瘤内氧化应激而实现的。所有这些组合效应导致显著有效的肿瘤抑制结果。本研究丰富了声敏剂的研究，证明了声敏剂可以通过电荷分离工程策略进行合理优化。
The development and optimization of sonosensitizers for elevating intratumoral reactive oxygen species (ROS) are definitely appealing in current sonodynamic therapy (SDT). Given this, branched vanadium tetrasulfide (VS4) nanodendrites with a narrower bandgap (compared with the most extensively explored sonosensitizers) are presented as a new source of sonosensitizer, which allows a more effortless separation of sono‐triggered electron–hole pairs for ROS generation. Specifically, platinum (Pt) nanoparticles and endogenous high levels of glutathione (GSH) are rationally engineered to further optimize its sono‐sensitized performance. As cocatalyst, Pt is conducive to trapping electrons, whereas GSH, as a natural hole‐scavenger, tends to capture holes. Compared with the pristine VS4 sonosensitizer, the GSH‐Pt‐VS4 nanocomposite can greatly prolong the lifetime of the charge and confer a highly efficacious ROS production activity. Furthermore, such nanoplatforms are capable of reshaping tumor microenvironments to realize ROS overproduction, contributed by overcoming tumor hypoxia to improve SDT‐triggered singlet oxygen production, catalyzing endogenic hydrogen peroxide into destructive hydroxyl radicals for chemodynamic therapy, and depleting GSH to amplify intratumoral oxidative stress. All these combined effects result in a significantly efficient tumor suppression outcome. This study enriches sonosensitizer research and proves that sonosensitizers can be rationally optimized by charge separation engineering strategy.