Letter by Tsuda regarding article, Oxidative stress biomarkers of brain damages: hyperacute plasma F2-isoprostane predicts infarct growth in stroke.
Letter by Tsuda regarding article, Oxidative stress biomarkers of brain damages: hyperacute plasma F2-isoprostane predicts infarct growth in stroke.
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Tsuda 就文章《脑损伤的氧化应激生物标志物：超急性血浆 F2-异前列烷预测中风中的梗塞生长》发表的信函。
DOI：
10.1161/strokeaha.118.021400
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发表时间：
2018
期刊：
影响因子：
8.3
通讯作者：
Kazushi Tsuda
中科院分区：
文献类型：
--
作者：
Eriko Satomi;Hiromichi Matsuoka et al.;Hiromichi Matsuoka et al.;ｈHiromichi Matsuoka et al.;Hiromichi Matsuoka;Kazushi Tsuda;Kazushi Tsuda
我们怀着极大的兴趣阅读了Lorenzano博士等人关于急性缺血性卒中患者氧化应激与梗死生长（IG）之间关系的文章。通过扩散加权磁共振成像或计算机断层扫描方法评估梗死体积。他们的研究结果表明，血浆F2异丙烷（F2- isop）（氧化应激诱导的脂质过氧化的生物标志物）的基线与症状发作后9小时内的IG和最终梗死体积显著相关。此外，作者发现，在多元回归模型中，高急性血浆F2-isoP升高可能预测IG的发生和IG体积。作者提出，测定血浆F2-isoP可能有助于急性缺血性脑卒中患者根据缺血性损伤的相对严重程度和预期进展进行分层。有证据表明，内皮功能受损可能与急性缺血性卒中密切相关。Willmot等人2在系统回顾了25项关于一氧化氮供体和l -精氨酸在实验性卒中中的作用的研究后发现，在永久性和短暂性缺血模型中，一氧化氮供体的施用显著降低了脑梗死总体积。这一发现强烈表明，内皮功能可能在预防中风进展中起着至关重要的作用。然而，有研究表明，在顽固性高血压患者中，血浆8-异前列腺素水平与血流介导的肱动脉扩张（一项内皮功能的临床指标）呈负相关。Cherneva等人也观察到尿异前列腺素与阻塞性睡眠呼吸暂停患者血流介导的扩张呈负相关。在之前的一项研究中，我们发现在正常和高血压患者中，血浆F2-isoP水平与血浆一氧化氮代谢物浓度呈负相关
We read with great interest the article by Dr Lorenzano et al1 dealing with the relationship between oxidative stress and infarct growth (IG) in patients with of acute ischemic stroke. The infarct volume was evaluated by diffusion-weighed magnetic resonance imaging or computed tomographic scan methods. The results of their study demonstrated that baseline of plasma F2 isoproatane (F2-isoP), a biomarker of oxidative stress–induced lipid peroxidation, significantly correlated with both IG within 9 hours of symptom onset and final infarct volume. In addition, the authors showed that, in the multivariate regression models, elevated hyperacute plasma F2-isoP might predict the occurrence of IG and IG volume. The authors proposed that measuring plasma F2-isoP might be helpful in the acute setting to stratify patients with acute ischemic stroke for relative severity of ischemic injury and expected progression.Evidence indicates that impaired endothelial function may strongly be related to acute ischemic stroke. Willmot et al2 demonstrated that in a systemic review of 25 studies about the effects of nitric oxide donors and L-arginine in experimental stroke, the administration of nitric oxide donors significantly reduced total cerebral infarct volume both in permanent and transient models of ischemia. The finding strongly suggests that endothelial function might have a crucial role in preventing the progression of stroke. However, it has been demonstrated that levels of plasma 8-isoprostane levels were inversely correlated with flow-mediated dilatation of the brachial artery (a clinical index of endothelial function) in subjects with resistant hypertension. 3 Cherneva et al4 also observed that urinary isoprostanes were inversely correlated with flow-mediated dilatation in patients with obstructive sleep apnea. In a study presented previously, we showed that plasma F2-isoP levels were inversely correlated with plasma nitric oxide metabolite concentration in normotensive and hypertensive