The multifunctional role of IGF-1 in peripheral nerve regeneration
The multifunctional role of IGF-1 in peripheral nerve regeneration
复制标题
DOI：
10.1179/016164104225013851
复制
发表时间：
2004-03-01
影响因子：
1.9
通讯作者：
Rabinovsky, ED
中科院分区：
文献类型：
--
作者：
Rabinovsky, ED
周围神经再生的要素包括神经生长、肌肉卫星细胞增殖和分化以及血管生长的复杂组合。越来越多的证据表明，生长因子可能在再生反应中的多个水平上起作用。影响多个细胞过程的一个这样的因素是胰岛素样生长因子（IGF-1）。作为神经营养因子，已知IGF-1促进神经伸长和分支。IGF-1作为一种肌源性因子，促进卫星细胞增殖、分化和肌肉肥大。作为血管生成因子，已知IGF-1通过激活VEGF和VEGF受体促进再生骨骼肌中的血管生成。此外，最近的研究表明，IGF-1也可能促进肌肉干细胞在再生过程中的激活。这篇综述将概述IGF-1影响多层再生反应的途径，以及这些途径如何收敛以促进神经再生。
The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cell processes is insulin-like growth factor (IGF-1). As a neurotrophic factor IGF-1 is known to promote nerve elongation and branching. As a myogenic factor, IGF-1 promotes satellite cell proliferation, differentiation and muscle hypertrophy. As an angiogenic factor, IGF-1 is known to promote angiogenesis in regenerating skeletal muscle by activating VEGF and VEGF receptors. Additionally, recent studies show that IGF-1 may also promote the activation of muscle stem cells during the regenerative process. This review will outline the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of nerves.