Dopamine neurons encode performance error in singing birds.
Dopamine neurons encode performance error in singing birds.
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DOI：
10.1126/science.aah6837
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发表时间：
2016-12-09
期刊：
影响因子：
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通讯作者：
Goldberg JH
中科院分区：
文献类型：
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作者：
Gadagkar V;Puzerey PA;Chen R;Baird-Daniel E;Farhang AR;Goldberg JH
许多行为都是通过将绩效与内部目标相匹配的尝试和错误来学习的。然而，绩效评估的神经机制仍然知之甚少。我们记录了基底神经节投射多巴胺神经元在唱歌斑胸草雀，因为我们控制感知的歌曲质量与扭曲的听觉反馈。多巴胺活动在扭曲的音节后被阶段性抑制，这与比预期更差的结果一致，并且在歌曲的精确时刻被阶段性激活，当预测的失真没有发生时，这与比预期更好的结果一致。误差响应大小取决于失真概率。因此，多巴胺能错误信号可以评估不是为了奖励而学习的行为，而是通过将表现结果与内部目标相匹配来学习的行为。
Many behaviors are learned through trial and error by matching performance to internal goals. Yet neural mechanisms of performance evaluation remain poorly understood. We recorded basal ganglia projecting dopamine neurons in singing zebra finches as we controlled perceived song quality with distorted auditory feedback. Dopamine activity was phasically suppressed after distorted syllables, consistent with a worse-than-predicted outcome, and was phasically activated at the precise moment of the song when a predicted distortion did not occur, consistent with a better-than-predicted outcome. Error response magnitude depended on distortion probability. Thus dopaminergic error signals can evaluate behaviors that are not learned for reward and are instead learned by matching performance outcomes to internal goals.