Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension
Dietary isoflavones intake is inversely associated with non-alcoholic fatty liver disease, hyperlipidaemia and hypertension
复制标题
膳食异黄酮摄入量与非酒精性脂肪肝、高脂血症和高血压呈负相关
DOI：
10.1080/09637486.2021.1910630
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发表时间：
2021-04
影响因子：
3.9
通讯作者：
Rennan Feng
中科院分区：
文献类型：
--
作者：
Xuemei Wang;Yan Wang;Weili Xu;Li Lan;Yuzheng Li;Liang Wang;Xiaowei Sun;Chao Yang;Yongshuai Jiang;Rennan Feng
摘要本研究调查了总黄酮及其类别（大豆黄酮、染料木素、黄豆黄素）摄入量与代谢紊乱风险之间的关系。我们使用了来自营养健康地图集项目的6786名中国成年人的数据。我们进行了多元逻辑回归和限制性三次样条模型，评估了每种胆固醇类代谢紊乱（非酒精性脂肪肝（NAFLD）、胆固醇血症、高血压、糖尿病和超重/肥胖）的风险。较高的总黄酮、大豆苷元和染料木黄酮摄入量与NAFLD呈负相关（p <0.05）。较高的总黄酮、大豆苷元、染料木素和黄豆黄素摄入量也与高血压（p <0.01）和高血压（p <0.01）呈负相关。剂量反应分析显示，总黄酮，大豆苷元，染料木素和黄豆黄素的摄入量与代谢紊乱的风险呈非线性趋势。总之，总黄酮，大豆苷元和染料木素摄入量与NAFLD，高血压和高血压呈负相关。大豆黄素与高血压和高血脂呈负相关。
Abstract This study investigated associations between total isoflavones and their categories (daidzein, genistein, glycitein) intake and the risks for metabolic disorders. We used the data of 6786 Chinese adults from the Nutrition Health Atlas Project. We performed multiple logistic regression and restricted cubic spline models assessing the risks for metabolic disorders (non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes and overweight/obesity) in each category of isoflavones. Higher total isoflavones, daidzein and genistein intake were inversely associated with NAFLD (p < .05). Higher total isoflavones, daidzein, genistein and glycitein intake were also inversely associated with hyperlipidaemia (p < .01) and hypertension (p < .01). Dose-response analyses revealed that total isoflavones, daidzein, genistein and glycitein intakes were associated with the risks of metabolic disorders in a nonlinear trend. In conclusion, total isoflavones, daidzein and genistein intake were inversely associated with NAFLD, hyperlipidaemia and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.
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DOI：
10.1016/s0140-6736(18)32225-6
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Risk Factor Collaborators
通讯作者：
GBD 2017 Risk Factor Collaborators
影响因子：
5
作者：
Lee-Jane W. Lu;Nai-Wei Chen;F. Nayeem;M. Nagamani;K. Anderson
通讯作者：
Lee-Jane W. Lu;Nai-Wei Chen;F. Nayeem;M. Nagamani;K. Anderson
影响因子：
5.9
作者：
Ramdath DD;Padhi EM;Sarfaraz S;Renwick S;Duncan AM
通讯作者：
Duncan AM
影响因子：
7.5
作者：
Liu, Huanhuan;Zhong, Huijia;Jiang, Zhuoqin
通讯作者：
Jiang, Zhuoqin
影响因子：
8.3
作者：
Lelong, Helene;Blacher, Jacques;Kesse-Guyot, Emmanuelle
通讯作者：
Kesse-Guyot, Emmanuelle