Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3

Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3
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细胞质中可持续生物合成聚N-乙酰乳糖胺糖蛋白用于检测肿瘤生物标志物半乳糖凝集素3的微生物平台的构建和优化

DOI:
10.1039/d0gc04331a
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发表时间:
2021-02
期刊:
影响因子:
9.8
通讯作者:
Huang Di
Huang Di
中科院分区:
化学1区
文献类型:
--
作者:
Yuan Jian;Jiang Xiaolong;Zhang Huijing;Bai Jing;Zhang Jing;Wang Yuhui;Lu Gege;Xu Huimin;Liu Huanhuan;Liu Bin;Huang Di

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半乳糖凝集素-3(Galectin-3,Gal-3)是β-半乳糖苷结合凝集素家族的成员,参与肿瘤血管生成和转移,被认为是早期癌症的诊断生物标志物和有希望的治疗靶点。Gal-3识别聚-N-乙酰乳糖胺(
Galectin-3 (Gal-3), a member of the β-galactoside-binding lectin family, involved in tumor angiogenesis and metastasis, is considered a diagnostic biomarker and a promising treatment target for early cancer. Gal-3 recognizes the poly-N-acetyllactosamine (
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