Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids.
Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids.
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DOI：
10.1021/ol202376m
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发表时间：
2011-10-21
期刊：
影响因子：
5.2
通讯作者：
Carlson EE
中科院分区：
文献类型：
--
作者：
Trader DJ;Carlson EE
Although the carboxylic acid moiety is prevalent in many biologically produced molecules, including natural products and proteins, methods to chemoselectively target this functional group have remained elusive. Generally, strategies that utilize carboxylate nucleophilicity also promote reactions with other nucleophiles such as amines and hydroxyls. A reagent was sought to facilitate the selective isolation of carboxylic acid-containing compounds from complex mixtures. Here, the development of siloxyl-ether functionalized solid supports is described.
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影响因子：
5.1
作者：
Mansson, Maria;Phipps, Richard K.;Nielsen, Kristian F.
通讯作者：
Nielsen, Kristian F.
影响因子：
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Ojima, Yuko;Yamaguchi, Kazuya;Mizuno, Noritaka
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Mizuno, Noritaka
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Araya, Juan J.;Montenegro, Gloria;Timmermann, Barbara N.
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作者：
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通讯作者：
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影响因子：
48
作者：
Carlson, Erin E.;Cravatt, Benjamin F.
通讯作者：
Cravatt, Benjamin F.