The Neuropathy of Multiple Myeloma: An Electrophysiological and Histological Study
The Neuropathy of Multiple Myeloma: An Electrophysiological and Histological Study
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多发性骨髓瘤的神经病变：电生理学和组织学研究
DOI：
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发表时间：
1971
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通讯作者：
J. Walsh
中科院分区：
文献类型：
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作者：
J. Walsh
本文对23例多发性骨髓瘤患者进行了临床和电生理研究。3名受试者有周围神经病变的临床和电生理证据，6名无神经病变临床证据的受试者有弥漫性运动和感觉传导障碍，总发病率为39%。对5名受影响的受试者进行腓肠神经活检。原发病理病变为轴突变性，导致有髓鞘和无髓鞘纤维丢失。
Clinical and electrophysiological studies were performed on 23 subjects with multiple myeloma. Three subjects had clinical and electrophysiological evidence of a peripheral neuropathy, and six subjects without clinical evidence of a neuropathy had a diffuse impairment of motor and sensory conduction, an overall incidence of 39%. Sural nerve biopsies were examined from five affected subjects. The primary pathological lesion was found to be axonal degeneration resulting in a loss of both myelinated and unmyelinated fibers.